DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpini1

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_033276.1	Gene:	Serpini1 / 20713	MGIID:	1194506	Length:	410	Species:	Mus musculus

Alignment Length:	405	Identity:	106/405 - (26%)
Similarity:	194/405 - (47%)	Gaps:	36/405 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLATVSQSKTVGYDAAADRNLL--AADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQT 71
            |.|||.::....|......|..:.  :.::||.:.....:||::.||.:|..:|.:..:||:|.|
Mouse     4 LELLALLALQSVVTGATFPDETITEWSVNMYNHLRGTGEDENILFSPLSIALAMGMMELGAQGST 68

  Fly    72 ASELQ-----QGLRLGPGDADAVSQRSGSYQQALTRDNNF--RLANNIYINENLEFKGSFRDVAQ 129
            ..|::     :||:.|    :..|........|...:|.:  :|||::::.........|..:.:
Mouse    69 RKEIRHSMGYEGLKGG----EEFSFLRDFSNMASAEENQYVMKLANSLFVQNGFHVNEEFLQMLK 129

  Fly   130 RQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQK 194
            ..|::.::.:||  ..|...|:.||:.|...||..:.|::..|..:..|...::|.|.:...|:.
Mouse   130 MYFNAEVNHVDF--SQNVAVANSINKWVENYTNSLLKDLVSPEDFDGVTNLALINAVYFKGNWKS 192

  Fly   195 AFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEVN--SLDA----KVVELPYQNPDFSMLLLL 253
            .||.:.|...||.......|::..|:....|.|.|.:  |.:|    :|:|:||:..:.||:|.|
Mouse   193 QFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLAL 257

  Fly   254 PNRKDGLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDF 318
            ..::..|.:|:..|..:.:.....::.:|||||.||:|:|...:.|:...|.|||..:|.:|.:.
Mouse   258 SRQEVPLATLEPLLKAQLIEEWANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANL 322

  Fly   319 GNM---YRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRS----KKFEADHPFVFAIK 376
            ..|   ..:|:|..:    ||:.:||.|.|.:....:|::  ..||.    .:...||||::.|:
Mouse   323 TAMSDKKELFLSKAV----HKSCIEVNEEGSEAAAASGMI--AISRMAVLYPQVIVDHPFLYLIR 381

  Fly   377 YKDS--IAFIGHIAN 389
            .:.|  |.|:|.:.|
Mouse   382 NRKSGIILFMGRVMN 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	99/380 (26%)
Serpini1	NP_033276.1	neuroserpin	23..410	CDD:239003	101/386 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030