DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpinf1

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_035470.3	Gene:	Serpinf1 / 20317	MGIID:	108080	Length:	417	Species:	Mus musculus

Alignment Length:	382	Identity:	85/382 - (22%)
Similarity:	159/382 - (41%)	Gaps:	45/382 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NLLAA-------DLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDAD 87
            |.|||       |||...::.....||::||.::.::::...:||:.:|.|.:.:.|..     |
Mouse    51 NKLAAAVSNFGYDLYRLRSSASPTGNVLLSPLSVATALSALSLGAEHRTESVIHRALYY-----D 110

  Fly    88 AVSQRS--GSYQQALTR----DNNFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYN 146
            .::...  .:|::.|..    :.|.:.|:.|.....|..|.||....::.:.:....|..:|..:
Mouse   111 LITNPDIHSTYKELLASVTAPEKNLKSASRIVFERKLRVKSSFVAPLEKSYGTRPRILTGNPRVD 175

  Fly   147 KRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSY-SAAWQKAFRLDKTEKRSFRTGS 210
            .:.   ||..|..:..|||.   |:.........:::.||:| ...|...|...||..:.|....
Mouse   176 LQE---INNWVQAQMKGKIA---RSTREMPSALSILLLGVAYFKGQWVTKFDSRKTTLQDFHLDE 234

  Fly   211 GQSVKVDTMWTLQN-FNYAEVNSLDAKVVELPYQNPDFSMLLLLP-NRKDGLRSLQQSLSGKNL- 272
            .::|:|..|...:. ..|...:.|:.|:.:||... ..|::..|| .....|..:::||:.:.:
Mouse   235 DRTVRVPMMSDPKAILRYGLDSDLNCKIAQLPLTG-SMSIIFFLPLTVTQNLTMIEESLTSEFIH 298

  Fly   273 -----LAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSHFINA 332
                 |..|.|:      :.:||..::|...|....:.:.:.::| ...||..:....|.  :..
Mouse   299 DIDRELKTIQAV------LTVPKLKLSFEGELTKSLQDMKLQSLF-ESPDFSKITGKPVK--LTQ 354

  Fly   333 VEHKANVEVTEAGVDQPLETGLLKGLFSRSKKFEADHPFVFAIKYKD--SIAFIGHI 387
            |||:|..|..|.|.......||.....:....:..:.||:|.::..|  ::.|||.|
Mouse   355 VEHRAAFEWNEEGAGSSPSPGLQPVRLTFPLDYHLNQPFLFVLRDTDTGALLFIGRI 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	84/380 (22%)
Serpinf1	NP_035470.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..41
Serpinf1	NP_035470.3	PEDF	39..414	CDD:239007	85/382 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100