DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpine1

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_032897.2	Gene:	Serpine1 / 18787	MGIID:	97608	Length:	402	Species:	Mus musculus

Alignment Length:	410	Identity:	112/410 - (27%)
Similarity:	182/410 - (44%)	Gaps:	36/410 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVIISCLLLLLATVS---------QSKTVGYDAAADRNLLAADLYNAVAADHLNENVVISPATI 56
            |:..::||:|.|..||         :|.|.  ..|.|   ....::..|.....:.|||.||..:
Mouse     3 MSSALACLILGLVLVSGKGFTLPLRESHTA--HQATD---FGVKVFQQVVQASKDRNVVFSPYGV 62

  Fly    57 QSSMALAFVGAKGQTASELQ--QGLRLG-PGDADAVSQRS----GSYQQALTRDNNFRLANNIYI 114
            .|.:|:..:...|:|..::|  .|.::. .|.|.|:.|.|    |.:.:     |....|:.|::
Mouse    63 SSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAHALRQLSKELMGPWNK-----NEISTADAIFV 122

  Fly   115 NENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTE 179
            ..:||....|.....:.|.:.:.::||......|..  ||..|...|.|.|:|:|....:::.|.
Mouse   123 QRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFI--INDWVERHTKGMISDLLAKGAVDELTR 185

  Fly   180 GVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWTLQNFNYAEV---NSLDAKVVELP 241
            .|:||.:.:|..|:..|....|.:|.|....|.:|.|..|.....|||.|.   :.|:..|||||
Mouse   186 LVLVNALYFSGQWKTPFLEASTHQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELP 250

  Fly   242 YQNPDFSMLLLLPNRKD-GLRSLQQSLSGKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKK 305
            ||....||.:..|..|| .|.:|...|..:.:....|.|::....::|||||:...:.|.||.:|
Mouse   251 YQGDTLSMFIAAPFEKDVHLSALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEK 315

  Fly   306 LGVHTMFSRD-GDFGNMYRMFVSHFINAVEHKANVEVTEAGVDQPLETGLLKGLFSRSKKFEADH 369
            ||:..|||.. .||.::..........|:: |..:||.|:|......|..:........:...|.
Mouse   316 LGMPDMFSATLADFTSLSDQEQLSVAQALQ-KVRIEVNESGTVASSSTAFVISARMAPTEMVIDR 379

  Fly   370 PFVFAIKYK--DSIAFIGHI 387
            .|:|.:::.  ::|.|:|.:
Mouse   380 SFLFVVRHNPTETILFMGQV 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	101/370 (27%)
Serpine1	NP_032897.2	SERPIN	29..402	CDD:294093	105/384 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020