DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and Serpind1

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	385	Identity:	95/385 - (24%)
Similarity:	175/385 - (45%)	Gaps:	37/385 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NLL----AADLYNAVAADH--LNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADA 88
            |:|    |.:||. |..|.  .::|:.|:|..|.::|.:..:|.:|:|..|:...|..    .|.
Mouse   106 NILNAKFAFNLYR-VLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLHF----RDF 165

  Fly    89 VSQRSGSYQ------------QALTRDN---NFRLANNIYINENLEFKGSFRDVAQRQFDSNIDK 138
            |: .|..|:            ..|.|.|   ..|..|.:||.:....:..|:...:..:.:...:
Mouse   166 VN-ASSKYEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQFPIREDFKAAMREFYFAEAQE 229

  Fly   139 LDFHPPYNKRTADGINRAVATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEK 203
            .:|..|.....|   |..:...|.|.|.:.|  |.::..|:.:|:|.:.:...|...|.::.|..
Mouse   230 ANFPDPAFISKA---NNHILKLTKGLIKEAL--ENIDPATQMLILNCIYFKGTWVNKFPVEMTHN 289

  Fly   204 RSFRTGSGQSVKVDTMWTLQNFNYAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLS 268
            .:||....:.|||..|.|..||..|....||..:::|.|.. ..|||:::|.:..|:::|:..|:
Mouse   290 HNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPRKLSGMKTLEAQLT 353

  Fly   269 GKNLLAEIGAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNMYRMFVSHFINAV 333
            .:.:.....:|:.:..|||||||.:.....|....|.:|:..:|:::|:...:....::  |:..
Mouse   354 PQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGISDQRIA--IDLF 416

  Fly   334 EHKANVEVTEAGVDQPLETGLLKGLFSRSKKFEADHPFVFAI-KYKDS-IAFIGHIANYA 391
            :|::.:.|.|.|......|.:.....|...:|..|.||:|.: :::.| :.|:|.:.|.|
Mouse   417 KHQSTITVNEEGTQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCLLFMGKVTNPA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	93/379 (25%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	94/383 (25%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020