Protein Alignment Spn43Ab and SERPINA3

DIOPT Version :10

• Sequence 1: NP_001027395.1
• Gene: Spn43Ab / 45040
• FlyBaseID: FBgn0024293
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 99/382 - (25%)
• Similarity: 162/382 - (42%)
• Gaps: 44/382 - (11%)

  Fly    33 AADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQRSGSYQ 97
            |..||..:.....::||:.||.:|.:::|...:||...|.:|:.:||:....:. :.::...|:|
Human    57 AFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTET-SEAEIHQSFQ 120

  Fly    98 QALTRDN------NFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRA 156
            ..|...|      ...:.|.:::.|.|.....|.:.|:|.:.|.....||......:..  ||..
Human   121 HLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKL--INDY 183

  Fly   157 VATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWT 221
            |...|.|||||:::.  |:.:|..|:||.:.:.|.|:..|....|.:..|.....:.|.| .|.:
Human   184 VKNGTRGKITDLIKD--LDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMV-PMMS 245

  Fly   222 LQNFN--YAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNL--------LAEI 276
            |.:..  |.....|...||||.|.. :.|.|.:||: :|.:..::..|..:.|        ..||
Human   246 LHHLTIPYFRDEELSCTVVELKYTG-NASALFILPD-QDKMEEVEAMLLPETLKRWRDSLEFREI 308

  Fly   277 GAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNM---YRMFVSHFINAVEHKAN 338
            |       |:.|||||::....|.....:||:...|:...|...:   ..:.||.    |.|||.
Human   309 G-------ELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQ----VVHKAV 362

  Fly   339 VEVTEAGVDQPLETG----LLKGLFSRSKKFEADHPFVFAIKYKD--SIAFIGHIAN 389
            ::|.|.|.:....|.    ||..|.........:.||:..|...|  :|.|:..:.|
Human   363 LDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTN 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	serpin42Dd-like_insects	27..390	CDD:381070	99/382 (26%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	99/382 (26%)
		RCL	369..394		5/24 (21%)
		O-glycosylated at one site	381..389		3/7 (43%)