DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn43Ab and SERPINA3

DIOPT Version :9

Sequence 1:	NP_001027395.1	Gene:	Spn43Ab / 45040	FlyBaseID:	FBgn0024293	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001076.2	Gene:	SERPINA3 / 12	HGNCID:	16	Length:	423	Species:	Homo sapiens

Alignment Length:	382	Identity:	99/382 - (25%)
Similarity:	162/382 - (42%)	Gaps:	44/382 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AADLYNAVAADHLNENVVISPATIQSSMALAFVGAKGQTASELQQGLRLGPGDADAVSQRSGSYQ 97
            |..||..:.....::||:.||.:|.:::|...:||...|.:|:.:||:....:. :.::...|:|
Human    57 AFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTET-SEAEIHQSFQ 120

  Fly    98 QALTRDN------NFRLANNIYINENLEFKGSFRDVAQRQFDSNIDKLDFHPPYNKRTADGINRA 156
            ..|...|      ...:.|.:::.|.|.....|.:.|:|.:.|.....||......:..  ||..
Human   121 HLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKL--INDY 183

  Fly   157 VATKTNGKITDILRAELLNDRTEGVIVNGVSYSAAWQKAFRLDKTEKRSFRTGSGQSVKVDTMWT 221
            |...|.|||||:::.  |:.:|..|:||.:.:.|.|:..|....|.:..|.....:.|.| .|.:
Human   184 VKNGTRGKITDLIKD--LDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMV-PMMS 245

  Fly   222 LQNFN--YAEVNSLDAKVVELPYQNPDFSMLLLLPNRKDGLRSLQQSLSGKNL--------LAEI 276
            |.:..  |.....|...||||.|.. :.|.|.:||: :|.:..::..|..:.|        ..||
Human   246 LHHLTIPYFRDEELSCTVVELKYTG-NASALFILPD-QDKMEEVEAMLLPETLKRWRDSLEFREI 308

  Fly   277 GAMSQQKVEVLLPKFSVTFGLGLEGPFKKLGVHTMFSRDGDFGNM---YRMFVSHFINAVEHKAN 338
            |       |:.|||||::....|.....:||:...|:...|...:   ..:.||.    |.|||.
Human   309 G-------ELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQ----VVHKAV 362

  Fly   339 VEVTEAGVDQPLETG----LLKGLFSRSKKFEADHPFVFAIKYKD--SIAFIGHIAN 389
            ::|.|.|.:....|.    ||..|.........:.||:..|...|  :|.|:..:.|
Human   363 LDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTN 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn43Ab	NP_001027395.1	SERPIN	30..387	CDD:238101	98/378 (26%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	99/382 (26%)
		RCL	369..394		5/24 (21%)
		O-glycosylated at one site	381..389		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010