DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox100B and SOX9

DIOPT Version :10

Sequence 1:NP_651839.1 Gene:Sox100B / 45039 FlyBaseID:FBgn0024288 Length:529 Species:Drosophila melanogaster
Sequence 2:NP_000337.1 Gene:SOX9 / 6662 HGNCID:11204 Length:509 Species:Homo sapiens


Alignment Length:581 Identity:170/581 - (29%)
Similarity:222/581 - (38%) Gaps:192/581 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DSSSSNCSKDRAKPVE-TLVLANYALKAEQKKAQGQGGRKEDER------ITTAVMKVLEGYDWN 60
            ||:.|.|........| |....|...|.|...      :||.|.      |..||.:||:||||.
Human    29 DSAGSPCPSGSGSDTENTRPQENTFPKGEPDL------KKESEEDKFPVCIREAVSQVLKGYDWT 87

  Fly    61 LVQASAKA-PTDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKK 124
            ||....:. .:.:.|.|:||||||||||||||||.::.|||||.|:||||:|||||:.|.:|:|:
Human    88 LVPMPVRVNGSSKNKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKR 152

  Fly   125 PFMEFAEKLRMTHKQEHPDYKYQPRRKKARVLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSN 189
            ||:|.||:||:.||::||||||||||:|                                 |..|
Human   153 PFVEEAERLRVQHKKDHPDYKYQPRRRK---------------------------------SVKN 184

  Fly   190 GQRRAGKGNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPC 254
            ||..|.:          |:..:|          .|..|..|:|.:                |||.
Human   185 GQAEAEE----------ATEQTH----------ISPNAIFKALQA----------------DSPH 213

  Fly   255 STASSMSSL--------------TPPATP-YNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYG 304
            | :|.||.:              |||.|| .:|.|..|.......|                   
Human   214 S-SSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRP------------------- 258

  Fly   305 VLLEAGRE------YVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGG---------YT 354
             |.|.||:      .|.|||:     |:.|.|..|.....:...:|.. ||:.|         ||
Human   259 -LPEGGRQPPIDFRDVDIGEL-----SSDVISNIETFDVNEFDQYLPP-NGHPGVPATHGQVTYT 316

  Fly   355 GSRVSYPAYSYPANGGHFATEEQQ-----QQQALQASEALNYKPAAADIDPKEIDQYFMDQMLPM 414
            ||.......:.||:.||....:||     .||..||       |.|....|:       .|..|.
Human   317 GSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQA-------PPAPQAPPQ-------PQAAPP 367

  Fly   415 TQHHHPHHTHPLHHPLHHSPPLNSSASLSSACSSASSQQPVAEYYEHLGYSP--AASSASQNPNF 477
            .|...|    |.....|....|:|....|......:.|...:.|.|...:||  .|.|....|::
Human   368 QQPAAP----PQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPHY 428

  Fly   478 GPQQPYANGAASMTPTLGDPAPQQELQSQQQEQQHQNPSQHH---------LWGTYTYVNP 529
            .|..|...                  :||.....|||.|.::         |:.|:||:||
Human   429 SPSYPPIT------------------RSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNP 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox100BNP_651839.1 HMG-box_SoxE 76..150 CDD:438840 52/73 (71%)
SOX9NP_000337.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67 12/43 (28%)
Sox_N 22..94 CDD:463586 23/70 (33%)
Dimerization (DIM). /evidence=ECO:0000305|PubMed:31194875 63..103 13/39 (33%)
PQA. /evidence=ECO:0000305|PubMed:31194875 63..103 13/39 (33%)
HMG-box_SoxE 104..178 CDD:438840 52/73 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..273 46/202 (23%)
Transactivation domain (TAM). /evidence=ECO:0000269|PubMed:31194875 224..307 25/108 (23%)
9aaTAD 1. /evidence=ECO:0000269|PubMed:31194875 275..284 5/13 (38%)
9aaTAD 2. /evidence=ECO:0000269|PubMed:31194875 290..298 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 330..415 23/102 (23%)
Transactivation domain (TAC). /evidence=ECO:0000269|PubMed:8640233 394..509 22/96 (23%)
9aaTAD 3. /evidence=ECO:0000269|PubMed:34342803 460..468 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 479..509
Blue background indicates that the domain is not in the aligned region.

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