Protein Alignment Sox100B and SOX4

DIOPT Version :10

• Sequence 1: NP_651839.1
• Gene: Sox100B / 45039
• FlyBaseID: FBgn0024288
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_003098.1
• Gene: SOX4 / 6659
• HGNCID: 11200
• Length: 474
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 130/499 - (26%)
• Similarity: 190/499 - (38%)
• Gaps: 151/499 - (30%)

  Fly    38 GGRKEDERITTAVMKVLEGYDWNLVQASAKAPTDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHL 102
            ||:.:|.             .|      .|.|:.    ||||||||||||:|..||.:.:|.|.:
Human    43 GGKADDP-------------SW------CKTPSG----HIKRPMNAFMVWSQIERRKIMEQSPDM 84

  Fly   103 QNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRK--------KARVLPSQ 159
            .|:|:||.|||.||.||||||.||:..||:||:.|..::|||||:||:|        .:....|.
Human    85 HNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKYRPRKKVKSGNANSSSSAAASS 149

  Fly   160 QSGE-----GGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAA----ADLGSCASTIS---- 211
            :.||     |||.|      ...|..|...|||:.|......|..|    |...||.|.::
Human   150 KPGEKGDKVGGSGG------GGHGGGGGGGSSNAGGGGGGASGGGANSKPAQKKSCGSKVAGGAG 208

  Fly   212 ------HANV----GSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPP 266
                  ||.:    |.......:..|...:...|.||:|:           |...|:...||...
Human   209 GGVSKPHAKLILAGGGGGGKAAAAAAASFAAEQAGAAALL-----------PLGAAADHHSLYKA 262

  Fly   267 ATPYNVAPSNAKASAANNPSLLL----RQLSE-----------------PVANAG------DGYG 304
            .||    .::|.||:|.:.|..|    :.|:|                 ||...|      |..|
Human   263 RTP----SASASASSAASASAALAAPGKHLAEKKVKRVYLFGGLGTSSSPVGGVGAGADPSDPLG 323

  Fly   305 VLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGGYTGSRVSYPAYSYPANG 369
            :..|.|.. .:....:..|:|:...|.|.|.....          :.||...|.:.||   |::.
Human   324 LYEEEGAG-CSPDAPSLSGRSSAASSPAAGRSPAD----------HRGYASLRAASPA---PSSA 374

  Fly   370 GHFATEEQQQQQALQASEALNYKPAAADIDPKEIDQYFMDQMLPMTQHHHPHHTHPLHHPLHHSP 434
            ...|           :|.|.::..:::.......|..|.|.:|.:                  :|
Human   375 PSHA-----------SSSASSHSSSSSSSGSSSSDDEFEDDLLDL------------------NP 410

  Fly   435 PLN-SSASLSSACSSASSQQPVAEYYEHLGYSPAASSASQNPNF 477
            ..| .|.||.|..||::..:.:     ...:.|.:.|..:.|::
Human   411 SSNFESMSLGSFSSSSALDRDL-----DFNFEPGSGSHFEFPDY 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	HMG-box_SoxE	76..150	CDD:438840	45/73 (62%)
SOX4	NP_003098.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		6/37 (16%)
		HMG-box_SoxC	58..133	CDD:438838	46/74 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..228		26/105 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..286		8/27 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..416		27/156 (17%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	426..434		0/12 (0%)