Protein Alignment Sox100B and SOX3

DIOPT Version :10

• Sequence 1: NP_651839.1
• Gene: Sox100B / 45039
• FlyBaseID: FBgn0024288
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_005625.2
• Gene: SOX3 / 6658
• HGNCID: 11199
• Length: 446
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 97/323 - (30%)
• Similarity: 136/323 - (42%)
• Gaps: 89/323 - (27%)

  Fly    70 TDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLR 134
            ||  ::.:||||||||||::..||.|:.:.|.:.|||:||.||..||.|.|::|:||::.|::||
Human   134 TD--QDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLR 196

  Fly   135 MTHKQEHPDYKYQPRRKKARVLPSQQ-SGEGG--SPGPEMTLSATMGSSGKPRSSNSNGQRRAGK 196
            ..|.:|:|||||:||||...:|...: |...|  .||.....:|...::....|....|||
Human   197 AVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAAAAAAAAAASSPVGVGQR---- 257

  Fly   197 GNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMS 261
                      ..|.:|.|..:|.                 |.||:::.|   |...|    .|||
Human   258 ----------LDTYTHVNGWANG-----------------AYSLVQEQL---GYAQP----PSMS 288

  Fly   262 S-LTPPATP----YNVA--------PSNAKA----SAANNPSLLLRQLSEPVANAGDGYGVLLEA 309
            | ..|||.|    |::|        |..|::    :||              |.|..|||.:..:
Human   289 SPPPPPALPPMHRYDMAGLQYSPMMPPGAQSYMNVAAA--------------AAAASGYGGMAPS 339

  Fly   310 GREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGGYTGSRV-SYPAYSYPANGGH 371
            .....|..    .||.....:.|....|...:          |..||.| |.|:...||...|
Human   340 ATAAAAAA----YGQQPATAAAAAAAAAAMSL----------GPMGSVVKSEPSSPPPAIASH 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	HMG-box_SoxE	76..150	CDD:438840	39/73 (53%)
SOX3	NP_005625.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..48
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..140		2/7 (29%)
		HMG-box_SoxB	137..212	CDD:438790	39/74 (53%)
		SOXp	208..302	CDD:463537	33/131 (25%)
		9aaTAD. /evidence=ECO:0000269|PubMed:34342803	399..407