Protein Alignment Sox100B and SOX1

DIOPT Version :10

• Sequence 1: NP_651839.1
• Gene: Sox100B / 45039
• FlyBaseID: FBgn0024288
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_005977.2
• Gene: SOX1 / 6656
• HGNCID: 11189
• Length: 391
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 119/510 - (23%)
• Similarity: 170/510 - (33%)
• Gaps: 234/510 - (45%)

  Fly    66 AKAPTDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFA 130
            |||..||    :||||||||||::..||.|:::.|.:.|||:||.||..||.:.:::|:||::.|
Human    44 AKANQDR----VKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEA 104

  Fly   131 EKLRMTHKQEHPDYKYQPRRKKARVLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAG 195
            ::||..|.:|||||||:||||...:|...          :.:|:..:.::|            ||
Human   105 KRLRALHMKEHPDYKYRPRRKTKTLLKKD----------KYSLAGGLLAAG------------AG 147

  Fly   196 KGNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSM 260
            .|.||..:|
Human   148 GGGAAVAMG-------------------------------------------------------- 156

  Fly   261 SSLTPPATPYNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQS 325
                                                  .|.|.|.        .|:|:   :.:|
Human   157 --------------------------------------VGVGVGA--------AAVGQ---RLES 172

  Fly   326 AGVQSGAEGGGAGQEMDFLENINGY--GGYTGSRVSYPAYSYPANGGHFATEEQQQQQALQASEA 388
            .|   ||.|||       ..::||:  |.|.||..:..|          |....|:.|.     |
Human   173 PG---GAAGGG-------YAHVNGWANGAYPGSVAAAAA----------AAAMMQEAQL-----A 212

  Fly   389 LNYKPAAADIDPKEIDQYFMDQMLPMTQHHHPHHTHPLHHP-----------------LHHSPPL 436
            ....|.|....|                |.||.|.|| |||                 |.:||..
Human   213 YGQHPGAGGAHP----------------HAHPAHPHP-HHPHAHPHNPQPMHRYDMGALQYSPIS 260

  Fly   437 NSSASLSS-----------ACSSASSQQPVAEYYEHLGYSPAASSAS------------QNPNFG 478
            ||...:|:           |.::|::....|.....:..:.||::||            ..|:..
Human   261 NSQGYMSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGS 325

  Fly   479 PQQPYANGAASMTPTLGD---------PA-----PQQELQSQQQEQQHQNPSQHH 519
            |..|    |.|..|..||         ||     |.....:..|.:.|..| ||:
Human   326 PPAP----AHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLP-QHY 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	HMG-box_SoxE	76..150	CDD:438840	38/73 (52%)
SOX1	NP_005977.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		5/11 (45%)
		HMG-box_SoxB	49..128	CDD:438790	43/82 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..249		12/51 (24%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P41225	342..350		0/7 (0%)