DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox100B and sox9b

DIOPT Version :9

Sequence 1:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_571719.1	Gene:	sox9b / 60642	ZFINID:	ZDB-GENE-001103-2	Length:	407	Species:	Danio rerio

Alignment Length:	517	Identity:	154/517 - (29%)
Similarity:	208/517 - (40%)	Gaps:	177/517 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DSSSSNCSKDRAKPVETLVLANYALKAEQKKAQGQGGRKEDER----ITTAVMKVLEGYDWNLVQ 63
            ||:.|.|:.           |.....:|..:|:....|.|.|:    |..||.:||:||||:||.
Zfish    23 DSAGSPCAS-----------AGSGSDSETPRAEPPLHRDEQEKFPVCIRDAVSQVLKGYDWSLVP 76

  Fly    64 ASAK-APTDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFM 127
            ...: :.:.:.|.|:||||||||||||||||.::.|||||.|:||||:|||||:.|.:.:|:||:
Zfish    77 MPVRVSGSGKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNEGEKRPFV 141

  Fly   128 EFAEKLRMTHKQEHPDYKYQPRRKKARVLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQR 192
            |.||:||:.||::||||||||||:|     |.:||...|...|.|
Zfish   142 EEAERLRVQHKKDHPDYKYQPRRRK-----SVKSGSAESEDGEQT-------------------- 181

  Fly   193 RAGKGNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETG-LDSPCS- 255
                                         ..|..|..::|..|      |.....|| |.||..
Zfish   182 -----------------------------QISTNALFRALQRA------ETPDSSTGELHSPGEH 211

  Fly   256 TASSMSSLTPPATPYNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVN 320
            :..|....|||.||....|..:||.......   |....|:.: |..:|.        |.|||:
Zfish   212 SGQSQGPPTPPTTPKTDLPVCSKADLKRERE---RDRERPLQD-GIDFGA--------VDIGEL- 263

  Fly   321 YQGQSAGVQS-----------------GAEG-GGAGQEMDFLENINGYGGYTGSRVSYP-AYSYP 366
                |:.|.|                 ||.| .|||..       :|||  :.:.:..| |.|..
Zfish   264 ----SSDVISNIEAFDVNEFDQYLPPHGAPGPAGAGFS-------SGYG--SAAWMHKPLASSSM 315

  Fly   367 ANGGHFATEEQQQQQALQASEALNYKPAAADIDPKEIDQYFMDQMLPMTQHHHPHHTHPLHHPLH 431
            ||.|     ||.||:|...:|.|:                                      |.|
Zfish   316 ANAG-----EQHQQRAQIKTEQLS--------------------------------------PGH 337

  Fly   432 HS--PPLNS--SASLSSACSSASSQQPVAEY-------YEHLGYSPAASSASQNPNFGPQQP 482
            :|  ||...  ||..|.|..:..|:|..|.|       |....|:|||::.:.:.:....||
Zfish   338 YSQQPPQQQFYSAPYSRAQYTEYSEQHSAYYSPYPTFSYSRPPYTPAAAADTAHTHHWDPQP 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	47/69 (68%)
sox9b	NP_571719.1	Sox_N	16..80	CDD:372113	21/67 (31%)
sox9b	NP_571719.1	SOX-TCF_HMG-box	90..160	CDD:238684	47/69 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6177
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I3937
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm24602
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45803
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1210
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.060