DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox100B and SOX18

DIOPT Version :9

Sequence 1:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_060889.1	Gene:	SOX18 / 54345	HGNCID:	11194	Length:	384	Species:	Homo sapiens

Alignment Length:	412	Identity:	115/412 - (27%)
Similarity:	155/412 - (37%)	Gaps:	141/412 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHK 138
            :..|:||||||||||:..|:.:::|.|.|.|:.|||.|||.||.|..::|:||:|.||:||:.|.
Human    82 ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHL 146

  Fly   139 QEHPDYKYQPRRK----KAR------VLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRR 193
            ::||:|||:||||    |||      :||.....:   |.||...:|
Human   147 RDHPNYKYRPRRKKQARKARRLEPGLLLPGLAPPQ---PPPEPFPAA------------------ 190

  Fly   194 AGKGNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTAS 258
            :|...|..:|....:...                                     ||..|....|
Human   191 SGSARAFRELPPLGAEFD-------------------------------------GLGLPTPERS 218

  Fly   259 SMSSL--------TPPATPYNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGV-LLEAGREYV 314
            .:..|        .|||.|.:.|....:|..|  |:.|.|       :.|..||. |.||.|...
Human   219 PLDGLEPGEAAFFPPPAAPEDCALRPFRAPYA--PTELSR-------DPGGCYGAPLAEALRTAP 274

  Fly   315 AIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGGYTGSRVSYPAYSYPANGGHFATEEQQQ 379
            ....:      ||:                     |.|..|:...||....|          ..:
Human   275 PAAPL------AGL---------------------YYGTLGTPGPYPGPLSP----------PPE 302

  Fly   380 QQALQASEALNYKPAA---ADIDPKEIDQYFMDQMLPMTQHHHPHHTHPLHHPLHHSPPLNSS-- 439
            ...|:::|.|.  |||   ||:|..|.|||     |..::........|.|..|....|...|
Human   303 APPLESAEPLG--PAADLWADVDLTEFDQY-----LNCSRTRPDAPGLPYHVALAKLGPRAMSCP 360

  Fly   440 --ASLSSACSSASSQQPVAEYY 459
              :||.||.|.|||    |.||
Human   361 EESSLISALSDASS----AVYY 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	37/69 (54%)
SOX18	NP_060889.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		1/5 (20%)
		SOX-TCF_HMG-box	84..155	CDD:238684	38/70 (54%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	87..100		10/12 (83%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	111..123		7/11 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..218		24/129 (19%)
		Important for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:P43680	166..231		15/122 (12%)
		Sox_C_TAD	193..382	CDD:288887	62/280 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..312		5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810