DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox100B and sox2

DIOPT Version :9

Sequence 1:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_998869.1	Gene:	sox2 / 407873	XenbaseID:	XB-GENE-484553	Length:	311	Species:	Xenopus tropicalis

Alignment Length:	328	Identity:	89/328 - (27%)
Similarity:	145/328 - (44%)	Gaps:	76/328 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 WNLVQASAKAPTDRK-----------------KEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSE 106
            :|:::...|.|..::                 .:.:||||||||||::..||.|:::.|.:.|||
Frog     2 YNMMETDLKPPAPQQASGGNSNSGSNNQSKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSE 66

  Fly   107 LSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKKARV-------LPSQQSGEG 164
            :||.||..||.|.:::|:||::.|::||..|.:|||||||:||||...:       ||......|
Frog    67 ISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPG 131

  Fly   165 GSPGPEMT--LSATMGSSGKPRS---SNSNGQRRAGKGNAAADLGSCASTISHANVGSNS----- 219
            .:|   ||  :.|::|:....|.   ::.||....|.|.....||    ...|..:.:::
Frog   132 ANP---MTSGVGASLGAGVNQRMDTYAHMNGWTNGGYGMMQEQLG----YPQHPGLSAHNAPQMQ 189

  Fly   220 ------------SDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPP---ATP 269
                        :.:.|::.:|.. :...:.|..:|......|.|..|...|.||.:||   ::.
Frog   190 PMHRYDVSALQYNSMSSSQTYMNG-SPTYSMSYSQQGAPGMSLGSMGSVVKSESSSSPPVVTSSS 253

  Fly   270 YNVAPSNAKASAANNPSLLL--RQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGA 332
            ::.||..| ....:..|:.|  .::.||.|.:      .|...:.|          |||.|...|
Frog   254 HSRAPCQA-GDLRDMISMYLPGAEVPEPAAQS------RLHMSQHY----------QSASVAGTA 301

  Fly   333 EGG 335
            ..|
Frog   302 ING 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	36/69 (52%)
sox2	NP_998869.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		4/37 (11%)
		SOX-TCF_HMG-box	36..107	CDD:238684	37/70 (53%)
		SOXp	106..194	CDD:372055	21/94 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..259		8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910