Protein Alignment Sox100B and sox17b

DIOPT Version :10

• Sequence 1: NP_651839.1
• Gene: Sox100B / 45039
• FlyBaseID: FBgn0024288
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_988849.1
• Gene: sox17b / 394440
• XenbaseID: XB-GENE-484865
• Length: 376
• Species: Xenopus tropicalis
• Alignment Length: 467
• Identity: 123/467 - (26%)
• Similarity: 184/467 - (39%)
• Gaps: 138/467 - (29%)

  Fly    38 GGRKEDERI--TTAVMKVLEGYDW-----------NLVQASAKAPTDRKKEHIKRPMNAFMVWAQ 89
            ||...|::.  ..:|..::..|:|           ...:|.:.....:.:..|:||||||||||:
 Frog     6 GGYASDDQFHGNCSVPIMMGQYEWTDPLTMFQDAKTKKEAGSANSRGKAEARIRRPMNAFMVWAK 70

  Fly    90 AARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKKAR 154
            ..|:.:::|.|.|.|:||||.|||.||:|..:.|:||:|.||:||:.|.|::|||||:||||| :
 Frog    71 DERKRLAQQNPDLHNAELSKMLGKSWKSLTLASKRPFVEEAERLRVQHIQDYPDYKYRPRRKK-Q 134

  Fly   155 VLPSQQSGEG-----GSPGPE-MTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGSCASTISHA 213
            |...::..||     ..|||: |..:|.:|.:.|.:.|..|.|:               |.|:.|
 Frog   135 VKRMKREEEGFLPSADIPGPQVMGCNAMVGQNYKMQYSGQNSQQ---------------SQITPA 184

  Fly   214 NVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLT--PPATPYNVAPSN 276
            ....:.:.|                     .....|.:.|....|..||:|  |||.
 Frog   185 GYFEDHNPV---------------------GYYYRGYNVPEYYMSQNSSVTCGPPAQ-------- 220

  Fly   277 AKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEM 341
                                              .||.|: ..|:.......|..|.....|::|
 Frog   221 ----------------------------------GEYQAL-SYNFNSSYIPYQQNASAPAMGKQM 250

  Fly   342 DFLENI---NGYGGYTGSRVSYPAYSYPANGGHFATE--------EQQQQQALQASEAL---NYK 392
            ...|||   :...|..|.:||...|    ||..:..|        :.:|..:|..|:.:   ||.
 Frog   251 AVKENIIQESPEHGIMGCQVSPQMY----NGQMYVPECAKTHPVAQTEQHSSLHQSQQMVTQNYL 311

  Fly   393 PA------AADIDPKEIDQYFMDQMLPMTQHHHPHHTHPLHHPLHHSPPLNSSASLSSACSSASS 451
            |:      .:|||..|.|||.|         :.|.....|.:.:.......|:..|.|..|.|:|
 Frog   312 PSQQDGHLESDIDKTEFDQYLM---------YEPKSDTELIYTIDQDSGAYSTNLLPSLISEANS 367

  Fly   452 QQPVAEYYEHLG 463
                ..||::.|
 Frog   368 ----VCYYDYCG 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	HMG-box_SoxE	76..150	CDD:438840	42/73 (58%)
sox17b	NP_988849.1	HMG-box_SoxF_SOX17	52..132	CDD:438850	43/79 (54%)
		PABP-1234	<80..250	CDD:130689	66/249 (27%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q9H6I2	326..334		5/16 (31%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250|UniProtKB:O42601	327..331		2/3 (67%)