DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox100B and Sox17

DIOPT Version :9

Sequence 1:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001101372.1	Gene:	Sox17 / 312936	RGDID:	1305371	Length:	423	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	135/545 - (24%)
Similarity:	176/545 - (32%)	Gaps:	196/545 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDSSSSNCSKDRAKPVETLVLANYALKAEQKKAQGQGGRKEDERITTAVMKVLEGYDW------ 59
            ||...:...|.|:::|               :.||            .|||..|....|
  Rat     1 MSSPDAGYASDDQSQP---------------RSAQ------------PAVMAGLGPCPWAESLSS 38

  Fly    60 -------NLVQASAKAPTD-----RKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLG 112
                   ..|.||:.||..     :.:..|:||||||||||:..|:.:::|.|.|.|:||||.||
  Rat    39 LGDVKVKGEVVASSGAPAGTSSRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLG 103

  Fly   113 KLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKK------------ARVLPSQQSG--- 162
            |.||.|..::|:||:|.||:||:.|.|:||:|||:|||:|            ...|...|:|
  Rat   104 KSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALAEPQAGALG 168

  Fly   163 -EGGS--------PGPEMTLSATMGSSGKPRSSNSNGQRR---AGKGNAAADLGSCASTISHANV 215
             |||.        |.||....|     |.|..|...|...   .|.|..|.|.....:..:....
  Rat   169 PEGGRVAMDGLGLPFPEPGYPA-----GPPLMSPHMGAHYRDCQGLGAPALDGYPLPTPDTSPLD 228

  Fly   216 GSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATPYNVAPSNAKAS 280
            |......|    |...|...|.|:         |..:....:.......|.|.|..|.|.   .|
  Rat   229 GVEQDPAF----FAAPLPGDCPAA---------GAYTYAQVSDYAVPAEPSAGPMRVGPD---PS 277

  Fly   281 AANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLE 345
            .:..|.:    |:.|.|
  Rat   278 GSAMPGI----LAPPSA------------------------------------------------ 290

  Fly   346 NINGYGGYTGSRVSYPAYSYPANGGHFATEEQQQQQALQASEALNYKPAAADIDPKEIDQYFMDQ 410
             ::.|.|..||    ||.|  |..|..|    |.||.||                        .|
  Rat   291 -LHLYYGAMGS----PAAS--AGRGFHA----QPQQPLQ------------------------PQ 320

  Fly   411 MLPMTQHHHPHHTHPLHHPLHHSPPLNSSASLSSACSSASS-QQPVA----------EYYEHLGY 464
            ..|......|...||.|.|...|||..     :..|...:. .||..          |.|.|..|
  Rat   321 PPPPPPPPPPPQQHPTHGPGQPSPPPE-----ALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVY 380

  Fly   465 SPAASSASQNPNFGPQQPYANGAAS 489
            .|......|..:.|.....::||.|
  Rat   381 KPEMGLPYQGHDCGVNLSDSHGAIS 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	39/69 (57%)
Sox17	NP_001101372.1	SOX-TCF_HMG-box	67..138	CDD:238684	40/70 (57%)
Sox17	NP_001101372.1	Sox17_18_mid	203..253	CDD:403331	11/62 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810