DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox100B and Sox10

DIOPT Version :9

Sequence 1:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_062066.1	Gene:	Sox10 / 29361	RGDID:	3735	Length:	466	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	153/492 - (31%)
Similarity:	203/492 - (41%)	Gaps:	124/492 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KAQGQGGRKEDER----ITTAVMKVLEGYDWNLVQASAKA-PTDRKKEHIKRPMNAFMVWAQAAR 92
            |.:.|.|..:|::    |..||.:||.||||.||....:. ...:.|.|:|||||||||||||||
  Rat    55 KKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAAR 119

  Fly    93 RVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKKARVLP 157
            |.::.|||||.|:||||:|||||:.|.:|||:||:|.||:|||.||::||||||||||:|.   .
  Rat   120 RKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKN---G 181

  Fly   158 SQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGSCASTISHANVGSNSSDV 222
            ....||...||.|                       ..:|.|||
  Rat   182 KAAQGEAECPGGE-----------------------TDQGGAAA--------------------- 202

  Fly   223 FSNEAFMKSLNSACAASLMEQSLIETGLDSPCS-------TASSMSSLTPPATPYNVAPSNAKAS 280
              .:|..||.:       ::....|.|  ||.|       :..|....|||.||.....|.....
  Rat   203 --IQAHYKSAH-------LDHRHPEEG--SPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADP 256

  Fly   281 AANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLE 345
            ..:..||            |:|....::.|.  |.|||::::     |.|..|.... .|:|...
  Rat   257 KRDGRSL------------GEGGKPHIDFGN--VDIGEISHE-----VMSNMETFDV-TELDQYL 301

  Fly   346 NINGYGGYTGSRVSYPAYSYPAN------GGHFATEEQQQQQALQASEALNYKPAAADIDPKEID 404
            ..||:.|:.|   ||.|..|..:      .||.|...:....||..            :.|..:|
  Rat   302 PPNGHPGHVG---SYSAAGYGLSSALAVASGHSAWISKPPGVALPT------------VSPPAVD 351

  Fly   405 QYFMDQMLPMTQHHHPHHT-HPLHHPLHH---SPPLNSSA--SLSSACSSASSQQPVAEYYEHLG 463
            .....:.........||:| .|....:.:   |.|...||  |:|......|..||...||.|.|
  Rat   352 AKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHAG 416

  Fly   464 YSPAASSA------SQNPNF-GPQQPYANGAASMTPT 493
            .:....||      ||.|.: ....|..:|..|.:||
  Rat   417 QASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPT 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	50/69 (72%)
Sox10	NP_062066.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		4/11 (36%)
		Sox_N	12..93	CDD:289229	15/37 (41%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	62..102		12/39 (31%)
		SOX-TCF_HMG-box	103..173	CDD:238684	50/69 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..198		21/63 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..275		16/75 (21%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	228..310		24/101 (24%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	353..466		27/101 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..375		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5872
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm45041
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45803
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1210
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910