Protein Alignment Sox100B and Sox17

DIOPT Version :10

• Sequence 1: NP_651839.1
• Gene: Sox100B / 45039
• FlyBaseID: FBgn0024288
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_035571.1
• Gene: Sox17 / 20671
• MGIID: 107543
• Length: 419
• Species: Mus musculus
• Alignment Length: 513
• Identity: 135/513 - (26%)
• Similarity: 181/513 - (35%)
• Gaps: 154/513 - (30%)

  Fly     1 MSDSSSSNCSKDRAKPVETLVLANYALKAEQKKAQGQGGRKEDERITTAVMKVLEGYDW------ 59
            ||...:...|.|:::|               :.||            .|||..|....|
Mouse     1 MSSPDAGYASDDQSQP---------------RSAQ------------PAVMAGLGPCPWAESLSP 38

  Fly    60 -------NLVQASAKAPTD-----RKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLG 112
                   ..|.||:.||..     :.:..|:||||||||||:..|:.:::|.|.|.|:||||.||
Mouse    39 LGDVKVKGEVVASSGAPAGTSGRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLG 103

  Fly   113 KLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKK------------ARVLPSQQSG--- 162
            |.||.|..::|:||:|.||:||:.|.|:||:|||:|||:|            ...|...|:|
Mouse   104 KSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALVEPQAGALG 168

  Fly   163 -EGGS--------PGPEMTLSATMGSSGKPRSSNSNGQRR---AGKGNAAADLGSCASTISHANV 215
             |||.        |.||....|     |.|..|...|...   .|.|..|.|.....:..:....
Mouse   169 PEGGRVAMDGLGLPFPEPGYPA-----GPPLMSPHMGPHYRDCQGLGAPALDGYPLPTPDTSPLD 228

  Fly   216 GSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATPYNVAP---SNA 277
            |......|    |...|...|.|:         |..:....:....|:.|||.|..|.|   ..|
Mouse   229 GVEQDPAF----FAAPLPGDCPAA---------GTYTYAPVSDYAVSVEPPAGPMRVGPDPSGPA 280

  Fly   278 KASAANNPS---LLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQ 339
            .......||   |....:..|.|:||.|:....:.        .:..|......|......|.||
Mouse   281 MPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQ--------PLQPQAPPPPPQQQHPAHGPGQ 337

  Fly   340 EMDFLENINGYGGYTGSRVSYPAYSYPANGGHFATEEQQQQQALQASEALNYKPAAADIDPKEID 404
            .                  |.|..:.|...|   ||..|..:.|            .::|..|.:
Mouse   338 P------------------SPPPEALPCRDG---TESNQPTELL------------GEVDRTEFE 369

  Fly   405 QYFMDQMLPMTQHHH---PHHTHPLHHPLHHSPPLNSSASLSSACSSASSQQPVAEYY 459
            ||     ||......   |:..|.....|.     :|..::||..|.|||    |.||
Mouse   370 QY-----LPFVYKPEMGLPYQGHDCGVNLS-----DSHGAISSVVSDASS----AVYY 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	HMG-box_SoxE	76..150	CDD:438840	42/73 (58%)
Sox17	NP_035571.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		10/52 (19%)
		HMG-box_SoxF_SOX17	62..142	CDD:438850	43/79 (54%)
		Sox17_18_mid	203..253	CDD:463454	11/62 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..356		15/81 (19%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q9H6I2	366..374		4/12 (33%)