Protein Alignment Sox100B and Sox12

DIOPT Version :9

• Sequence 1: NP_651839.1
• Gene: Sox100B / 45039
• FlyBaseID: FBgn0024288
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_035568.1
• Gene: Sox12 / 20667
• MGIID: 98360
• Length: 314
• Species: Mus musculus
• Alignment Length: 319
• Identity: 97/319 - (30%)
• Similarity: 133/319 - (41%)
• Gaps: 79/319 - (24%)

  Fly    67 KAPTDRKKEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAE 131
            |.|:.    ||||||||||||:|..||.:..|:|.:.|:|:||.||:.|:.|:||:|.||:..||
Mouse    34 KTPSG----HIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAE 94

  Fly   132 KLRMTHKQEHPDYKYQPRRKK----ARVLPSQQSGEGG----SPGPEMTLSATMGSSGKPRSSNS 188
            :||:.|..::|||||:||:|.    |:..|....|.||    .|||::.     |..|:..|...
Mouse    95 RLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLP-----GRGGRRASGGP 154

  Fly   189 NGQRRAGKGNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIET-GLDS 252
            .|      |.|||               ....|....|            .|:|..|:|| |.:.
Mouse   155 LG------GGAAA---------------PEDDDEDEEE------------ELLEVRLLETPGREL 186

  Fly   253 PCSTASSMSSLTPPATPYNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIG 317
            .....:..::..|.......:...|.||||   |..|.:..||            |...|..|..
Mouse   187 WRMVPAGRAARGPAERAQGPSGEGAAASAA---SPTLSEDEEP------------EEEEEEAATA 236

  Fly   318 EVNYQGQSAGVQSGAE---------GGGAGQEMDFLENINGYGGYTG-SRVSYPAYSYP 366
            |   :|:...|.||.|         .|.||.:...|:........:| |...:|.|..|
Mouse   237 E---EGEEETVVSGEEPLGFLSRMPPGPAGLDCSALDRDPDLLPPSGTSHFEFPDYCTP 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	38/69 (55%)
Sox12	NP_035568.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		2/9 (22%)
		SOX-TCF_HMG-box	39..110	CDD:238684	39/70 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..287		57/241 (24%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269|PubMed:18403418	282..314		4/11 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838615
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740