DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox100B and Sox11

DIOPT Version :9

Sequence 1:	NP_651839.1	Gene:	Sox100B / 45039	FlyBaseID:	FBgn0024288	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_033260.4	Gene:	Sox11 / 20666	MGIID:	98359	Length:	395	Species:	Mus musculus

Alignment Length:	361	Identity:	104/361 - (28%)
Similarity:	146/361 - (40%)	Gaps:	82/361 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 HIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQE 140
            ||||||||||||::..||.:.:|.|.:.|:|:||.|||.||.||||:|.||:..||:||:.|..:
Mouse    48 HIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMAD 112

  Fly   141 HPDYKYQPRRKKARVLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGS 205
            :|||||:| |||.:..|:.:...|.||......:......||..:.......:||.|.||.. |.
Mouse   113 YPDYKYRP-RKKPKTDPAAKPSAGQSPDKSAAGAKAAKGPGKKCAKLKAPAGKAGAGKAAQP-GD 175

  Fly   206 CASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATP- 269
            ||:..:...|..:..|...:|.....|.....|        :...|.|     :.|.|.||.|.
Mouse   176 CAAGKAAKCVFLDDDDEDDDEDDELQLRPKPDA--------DDDDDEP-----AHSHLLPPPTQQ 227

  Fly   270 --------YNVA---PSNAKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQG 323
                    |:||   .|...:|||.:|            .....|..:...||.|.:...:..|.
Mouse   228 QPPQLLRRYSVAKVPASPTLSSAAESP------------EGASLYDEVRAGGRLYYSFKNITKQQ 280

  Fly   324 Q---------------SAGVQSGAEGGGAGQEMD---FLENINGYGGYTGSRVSYPAYSYPANGG 370
            .               |....||:..|...::.|   |..::|.                 :.|.
Mouse   281 PPPAPPALSPASSRCVSTSSSSGSSSGSGAEDADDLMFDLSLNF-----------------SQGA 328

  Fly   371 HFATEEQQQQQALQASEALNYKPAAADIDPKEIDQY 406
            |.|.|     |.|.|..|.|...:..|   |::|.:
Mouse   329 HSACE-----QPLGAGAAGNLSLSLVD---KDLDSF 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	40/69 (58%)
Sox11	NP_033260.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SOX-TCF_HMG-box	48..119	CDD:238684	41/70 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..258		43/170 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..312		5/35 (14%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269\|PubMed:18403418	363..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810