Protein Alignment Sox100B and sox18

DIOPT Version :9

• Sequence 1: NP_651839.1
• Gene: Sox100B / 45039
• FlyBaseID: FBgn0024288
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001123409.1
• Gene: sox18 / 100170185
• XenbaseID: XB-GENE-483233
• Length: 362
• Species: Xenopus tropicalis
• Alignment Length: 425
• Identity: 112/425 - (26%)
• Similarity: 158/425 - (37%)
• Gaps: 142/425 - (33%)

  Fly    56 GYDWNLVQASAKAPTDRK--KEHIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNL 118
            ||.:        :|.:.|  ...|:||||||||||:..|:.:::|.|.|.|:.|||.||:.||||
 Frog    53 GYGY--------SPCEEKPGDPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKNL 109

  Fly   119 KDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKK-----ARVLPSQQSGEGGSPGPEMTLSATMG 178
            ..::|:||:|.||:||:.|.|:||:|||:|||||     .||.||
 Frog   110 SSAEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQAKKLKRVDPS-------------------- 154

  Fly   179 SSGKPRSSNSNGQRRAGKGNAAADLGSCASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQ 243
                |...| .|.|    |.|.|:|......  |...||...:.:
 Frog   155 ----PLLRN-EGYR----GQAMANLSHFRDL--HPLGGSGDLESY-------------------- 188

  Fly   244 SLIETGLDSPCSTASSMSSL--TPPATPYNVAPSNAKASAANNPSLLLRQLSEPVANAGDGYGVL 306
                 ||.:|     .||.|  ..|:.|....|.             :|:.::|..
 Frog   189 -----GLPTP-----EMSPLDVVEPSEPAFFPPH-------------MREEADPGP--------- 221

  Fly   307 LEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLENINGYGGYTGSRVSYPAYSYPANGGH 371
                          ::....||..|.|.......:.:..:.:..||:..:..:...|..|..|..
 Frog   222 --------------FRTYQHGVDFGQEKTLREISLPYSSSPSHMGGFLRTPTASAFYYNPHGGSP 272

  Fly   372 FATEEQQ-----QQQALQASEALNYKPAAADIDPKEIDQYFMDQMLPMTQHHHPHHTHPLHH--- 428
            ..|...|     :..||:|.:.|.......|.|..|.|||     |.|::...|.:..|:..
 Frog   273 ACTPLGQLSPPPEAPALEAMDHLGPAELWGDFDRNEFDQY-----LNMSRTQGPGYPFPMSKLGA 332

  Fly   429 ----PLHHSPPLNSSASLSSACSSASSQQPVAEYY 459
                |...|       ||.||.|.||:    |.||
 Frog   333 PRTIPCEES-------SLISALSDAST----AMYY 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox100B	NP_651839.1	SOX-TCF_HMG-box	76..146	CDD:238684	38/69 (55%)
sox18	NP_001123409.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68		4/22 (18%)
		SOX-TCF_HMG-box	67..138	CDD:238684	39/70 (56%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:P43680	70..83		10/12 (83%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:P43680	94..106		6/11 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..159		16/53 (30%)
		Important for transcriptional activation. /evidence=ECO:0000250|UniProtKB:P43680	149..209		23/120 (19%)
		Sox17_18_mid	173..222	CDD:371880	14/116 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910