Protein Alignment Pp4-19C and PPP3CC

DIOPT Version :10

• Sequence 1: NP_524803.1
• Gene: Pp4-19C / 45031
• FlyBaseID: FBgn0023177
• Length: 307
• Species: Drosophila melanogaster
• Sequence 2: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 115/284 - (40%)
• Similarity: 167/284 - (58%)
• Gaps: 21/284 - (7%)

  Fly    10 QIEQLKRCEIIKENEVKALCA-----KAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVG 69
            :::.||. .::||..::...|     ....||.:|..:..||:|:||||||||||:||.:||:||
Human    38 KVDVLKN-HLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVG 101

  Fly    70 GDVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKY 134
            |......|||:||:|||||:|:|..|.|.:||:.:|..:.|:|||||.|.:|..:.|..||..||
Human   102 GSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKY 166

  Fly   135 GSTAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSD 199
             |..|:..|.|.||.|.|:|:::.:..|||||:||.|..||.||.:||..|.|..||:|||||||
Human   167 -SEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSD 230

  Fly   200 PEDQTG--------WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNE----- 251
            |.:..|        ...:.||..|.:....|.:|.:.|::..|.|||:....|::.:...
Human   231 PSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGF 295

  Fly   252 -TVLTVWSAPNYCYRCGNVAAILE 274
             :::|::|||||.....|.||:|:
Human   296 PSLITIFSAPNYLDVYNNKAAVLK 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pp4-19C	NP_524803.1	MPP_PP2A_PP4_PP6	6..290	CDD:277360	115/284 (40%)
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	115/284 (40%)
		Catalytic. /evidence=ECO:0000305	52..343		111/269 (41%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521