DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp4-19C and PPP3CA

DIOPT Version :9

Sequence 1:	NP_001285489.1	Gene:	Pp4-19C / 45031	FlyBaseID:	FBgn0023177	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_000935.1	Gene:	PPP3CA / 5530	HGNCID:	9314	Length:	521	Species:	Homo sapiens

Alignment Length:	283	Identity:	117/283 - (41%)
Similarity:	168/283 - (59%)	Gaps:	25/283 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RCEIIKENEVK----------ALCAKAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGG 70
            |.:|:|.:.:|          .:..:...||.:|.|:..:|:||||||||||||:||.:||:|||
Human    42 RVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGG 106

  Fly    71 DVPEKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYG 135
            ......|||:||:|||||:|:|..|.|.|||:.||..:.|:|||||.|.:|:.:.|..||..||
Human   107 SPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKY- 170

  Fly   136 STAVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDP 200
            |..|:..|.:.||.|.|:|:::.:..||||||||.|..||.||.:||.:|.|..|||||:|||||
Human   171 SERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDP 235

  Fly   201 EDQTG--------WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNE------ 251
            .:..|        ...:.||..|.:....|.:|.:.|::..|.|||:....|::.:...
Human   236 LEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP 300

  Fly   252 TVLTVWSAPNYCYRCGNVAAILE 274
            :::|::|||||.....|.||:|:
Human   301 SLITIFSAPNYLDVYNNKAAVLK 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp4-19C	NP_001285489.1	MPP_PP2A_PP4_PP6	6..290	CDD:277360	117/283 (41%)
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	117/283 (41%)
		Catalytic. /evidence=ECO:0000305	56..340		113/269 (42%)
		SAPNY motif. /evidence=ECO:0000305\|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:17502104, ECO:0000269\|PubMed:22343722, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:26248042	327..336
		Calcineurin B binding. /evidence=ECO:0000269\|PubMed:12218175, ECO:0000269\|PubMed:12357034, ECO:0000269\|PubMed:17498738, ECO:0000269\|PubMed:23468591, ECO:0000269\|PubMed:27974827, ECO:0000269\|PubMed:8524402	341..369
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:18384083, ECO:0000269\|PubMed:19404396, ECO:0000269\|PubMed:25144868, ECO:0000269\|Ref.31	392..406
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..521
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820