DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp4-19C and Ppp3cc

DIOPT Version :9

Sequence 1:	NP_001285489.1	Gene:	Pp4-19C / 45031	FlyBaseID:	FBgn0023177	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	NP_001291920.1	Gene:	Ppp3cc / 19057	MGIID:	107162	Length:	522	Species:	Mus musculus

Alignment Length:	280	Identity:	112/280 - (40%)
Similarity:	163/280 - (58%)	Gaps:	20/280 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LKRCEIIKENEVKALCA-----KAREILVEEGNVQRVDSPVTVCGDIHGQFYDLKELFKVGGDVP 73
            |.:..::||..|:...|     ....||.:|..:..|::|:|||||:||||:||.:||:|||...
Mouse    41 LLKNHLVKEGRVEEEVALKIINDGAAILKQEKTMIEVEAPITVCGDVHGQFFDLMKLFEVGGSPS 105

  Fly    74 EKNYLFMGDFVDRGYYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSTA 138
            ...|||:||:|||||:|:|..|.|.:||:.:|..:.|:|||||.|.:|:.:.|..||..|| |..
Mouse   106 NTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTEYFTFKQECRIKY-SEM 169

  Fly   139 VWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQYLDQIRSIDRKQEVPHDGPMCDLLWSDPEDQ 203
            |:..|...||.|.|:|:::.:..|||||:||.|..|:.||.:||..|.|..||:||||||||.:.
Mouse   170 VYDACMHTFDCLPLAALLNQQFLCVHGGMSPEITCLEDIRKLDRFSEPPAFGPVCDLLWSDPLED 234

  Fly   204 TG--------WGVSPRGAGYLFGSDVVSQFNRTNDIDMICRAHQLVMEGFKWHFNE------TVL 254
            .|        ...:.||..|.|....|.:|.:.|.:..|.|||:....|::.:...      :::
Mouse   235 YGSEKTLEHYTHNTVRGCSYFFSYPAVCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLI 299

  Fly   255 TVWSAPNYCYRCGNVAAILE 274
            |::|||||.....|.||:|:
Mouse   300 TIFSAPNYLDVYNNKAAVLK 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp4-19C	NP_001285489.1	MPP_PP2A_PP4_PP6	6..290	CDD:277360	112/280 (40%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361	112/280 (40%)
		Catalytic. /evidence=ECO:0000305	52..343		109/269 (41%)
		PP2Ac	54..325	CDD:197547	108/267 (40%)
		SAPNY motif. /evidence=ECO:0000250\|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250\|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250\|UniProtKB:P16298	394..408
		Autoinhibitory segment. /evidence=ECO:0000250\|UniProtKB:P16298	409..416
		Autoinhibitory domain. /evidence=ECO:0000250\|UniProtKB:P16298	467..489
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910