DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfrp8 and Pdcd2

DIOPT Version :9

Sequence 1:	NP_001286828.1	Gene:	Zfrp8 / 45021	FlyBaseID:	FBgn0021875	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_113826.1	Gene:	Pdcd2 / 58934	RGDID:	61887	Length:	343	Species:	Rattus norvegicus

Alignment Length:	356	Identity:	145/356 - (40%)
Similarity:	200/356 - (56%)	Gaps:	42/356 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IDLGFAEKSDNGAW-LSNRYFPSKLGGQPAWLELEALPPTSQLQCSKCRAPKSFLAQLYAPF--E 64
            ::|||.|::.  || |.:..||||:||:||||.|..||....|.|::|..|.:||.|:|||.  .
  Rat     9 VELGFVEEAP--AWRLRSEQFPSKVGGRPAWLALAELPGPGALACARCGRPLAFLLQVYAPLPGR 71

  Fly    65 DEYNFHRSIYVFLCRNSDCQEAQNASNFTVLRSQLPRKNKFFSEEEPSDVGQPLPAVPCLK---- 125
            || .||||:::|.||...|     .:...|.|:||||||.|:|.|.||:.|.......||:
  Rat    72 DE-AFHRSLFLFCCREPLC-----CAGLRVFRNQLPRKNAFYSYEPPSETGASDTECVCLQLKSG 130

  Fly   126 -KLCAACGCHAPHACSKCKAIHYCSPEHQRAHWP-QHKPNCGAPEVATEK-PLTQIVFPEFEIVM 187
             .||..|||.||..||:||..||||.|||...|. .||..|...:..... |....:|||||||
  Rat   131 AHLCRVCGCLAPMTCSRCKQAHYCSKEHQTLDWQLGHKQACTQSDHLDHMVPDHNFLFPEFEIV- 194

  Fly   188 DSNPVESGEEDKDDEARLAEFQELESSGKTGDLSNVSEAEMDKYFGNSAAADDKTFRQFKKQTAA 252
                .|:.:|...:...:.::.|:     .|.:..|.|.|:|. .....:.:|..|::||.:.|.
  Rat   195 ----TETEDEIGPEVVEMEDYSEV-----IGSMEGVPEEELDS-MAKHESKEDHIFQKFKSKIAL 249

  Fly   253 EPDQIVRYKRGGQPLWITNTVKTVED--QLNKLPNCIACGGERQFEFQIMPQALTLLEDENL--- 312
            ||:||:||.||.:|:||:.     |:  |...:|:| :||.:|.||||:|||.|..|:.:.|
  Rat   250 EPEQILRYGRGIKPIWISG-----ENIPQEKDIPDC-SCGAKRIFEFQVMPQLLNHLKADRLGTS 308

  Fly   313 -DWGVLAVYTCAKSCPID-GYVEELLIKQDI 341
             |||:|||:|||:||.:. ||.||.:.|||:
  Rat   309 VDWGILAVFTCAESCSLGIGYTEEFVWKQDV 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfrp8	NP_001286828.1	zf-MYND	128..164	CDD:280009	20/36 (56%)
Zfrp8	NP_001286828.1	PDCD2_C	238..340	CDD:282100	49/108 (45%)
Pdcd2	NP_113826.1	zf-MYND	134..171	CDD:280009	20/36 (56%)
Pdcd2	NP_113826.1	PDCD2_C	225..338	CDD:282100	51/119 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341457
Domainoid	1	1.000	109	1.000	Domainoid score	I6255
eggNOG	1	0.900	-	-		E1_KOG2061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1951
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3268
OMA	1	1.010	-	-		QHG54449
OrthoDB	1	1.010	-	-		D1181470at2759
OrthoFinder	1	1.000	-	-		FOG0001596
OrthoInspector	1	1.000	-	-		oto96497
orthoMCL	1	0.900	-	-		OOG6_103745
Panther	1	1.100	-	-	LDO	PTHR12298
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4377
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770