Protein Alignment Vha68-2 and VMA1

DIOPT Version :9

• Sequence 1: NP_001246015.1
• Gene: Vha68-2 / 45012
• FlyBaseID: FBgn0263598
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_010096.1
• Gene: VMA1 / 851342
• SGDID: S000002344
• Length: 1071
• Species: Saccharomyces cerevisiae
• Alignment Length: 1067
• Identity: 394/1067 - (36%)
• Similarity: 492/1067 - (46%)
• Gaps: 463/1067 - (43%)

  Fly     4 LKRFD-DEERESKYGRVFAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYEE 67
            :||.. ::..||:||.:::||||||.||.|.|.||||||:||:..||||:||::||.||||||||
Yeast    12 IKRISLEDHAESEYGAIYSVSGPVVIAENMIGCAMYELVKVGHDNLVGEVIRIDGDKATIQVYEE 76

  Fly    68 TSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINELTESIYIPKGVNVPSLSRVASWE 132
            |:|:||||||||||||||||||||:|.:|:||||||||.|.|.::|||||:|::.|:|.|...|:
Yeast    77 TAGLTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKEESQSIYIPRGIDTPALDRTIKWQ 141

  Fly   133 FNPLNVKVGSHITGGDLYGLVHENTLV-KHKMIVNPRAKGTVRYIAPSGNYKVDDVVLETEFDGE 196
            |.|...:||.||:|||:||.|.||:|: .||:::.||::||:.:|||:|.|.:|:.:||.||||:
Yeast   142 FTPGKFQVGDHISGGDIYGSVFENSLISSHKILLPPRSRGTITWIAPAGEYTLDEKILEVEFDGK 206

  Fly   197 ITKHTMLQVWPVRQPRPVTEKLPANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQALS 261
            .:..|:...||||.||||||||.|::||||||||||:||||||||||.||||||||||||||:||
Yeast   207 KSDFTLYHTWPVRVPRPVTEKLSADYPLLTGQRVLDALFPCVQGGTTCIPGAFGCGKTVISQSLS 271

  Fly   262 KYSNSDVIIYVG----------------------------------------------------- 273
            ||||||.|||||
Yeast   272 KYSNSDAIIYVGCFAKGTNVLMADGSIECIENIEVGNKVMGKDGRPREVIKLPRGRETMYSVVQK 336

  Fly   274 ----------------------------------------------------------------- 273
                                                                             
Yeast   337 SQHRAHKSDSSREVPELLKFTCNATHELVVRTPRSVRRLSRTIKGVEYFEVITFEMGQKKAPDGR 401

  Fly   274 ----------------------------------------------------------------- 273
                                                                             
Yeast   402 IVELVKEVSKSYPISEGPERANELVESYRKASNKAYFEWTIEARDLSLLGSHVRKATYQTYAPIL 466

  Fly   274 ----------------------------------------------------------------- 273
                                                                             
Yeast   467 YENDHFFDYMQKSKFHLTIEGPKVLAYLLGLWIGDGLSDRATFSVDSRDTSLMERVTEYAEKLNL 531

  Fly   274 ----------------------------------------------------------------- 273
                                                                             
Yeast   532 CAEYKDRKEPQVAKTVNLYSKVVRGNGIRNNLNTENPLWDAIVGLGFLKDGVKNIPSFLSTDNIG 596

  Fly   274 ----------------------------------------------------------------- 273
                                                                             
Yeast   597 TRETFLAGLIDSDGYVTDEHGIKATIKTIHTSVRDGLVSLARSLGLVVSVNAEPAKVDMNGTKHK 661

  Fly   274 ----------------------------------------------------------------- 273
                                                                             
Yeast   662 ISYAIYMSGGDVLLNVLSKCAGSKKFRPAPAAAFARECRGFYFELQELKEDDYYGITLSDDSDHQ 726

  Fly   274 -----------CGERGNEMSEVLRDFPELSVEIDGVTESIMKRTALVANTSNMPVAAREASIYTG 327
                       ||||||||:|||.:||||..|:.|..|.|||||.||||||||||||||||||||
Yeast   727 FLLANQVVVHNCGERGNEMAEVLMEFPELYTEMSGTKEPIMKRTTLVANTSNMPVAAREASIYTG 791

  Fly   328 ITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVKCL 392
            |||:|||||.|.||||:|||:||||||||||||||.|||||.|:||||||:|||||||||:...|
Yeast   792 ITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKAVAL 856

  Fly   393 GNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYMRA 457
            |:|:|.||||||.||||.|||||||||:|||||.||||||||||||||||||||..:|||||...
Yeast   857 GSPDRTGSVSIVAAVSPAGGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNV 921

  Fly   458 LDDFYDKNFPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKITLEVAKLLKDDFLQQNSY 522
            |:.|||.|:|||..||.::||||...|:|.::||||||::|:::|||||:||.|:|:||||||.|
Yeast   922 LNKFYDSNYPEFPVLRDRMKEILSNAEELEQVVQLVGKSALSDSDKITLDVATLIKEDFLQQNGY 986

  Fly   523 SSYDRFCPFYKTVGMLRNIIDFYDMARHSVESTAQSENKITWNVIREAMGNIMYQLSSMKFKDPV 587
            |:||.|||.:||..|:|..|.::|.|:.:|      .|...|:.:.::.|::.:.:||.||.:|.
Yeast   987 STYDAFCPIWKTFDMMRAFISYHDEAQKAV------ANGANWSKLADSTGDVKHAVSSSKFFEPS 1045

  Fly   588 KDGEAKIKADFEQLHEDLQQAFRNLED 614
            : ||.::..:||:|...:|:.|....|
Yeast  1046 R-GEKEVHGEFEKLLSTMQERFAESTD 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-2	NP_001246015.1	V-ATPase_V1_A	16..606	CDD:273411	387/1044 (37%)
VMA1	NP_010096.1	V-ATPase_V1_A	24..>293	CDD:273411	174/268 (65%)
		Hom_end_hint	284..736	CDD:368334	0/451 (0%)
		V-ATPase_V1_A	<733..1063	CDD:273411	213/336 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343962
Domainoid	1	1.000	152	1.000	Domainoid score	I921
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S546
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm46705
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	LDO	PTHR43607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1628
SonicParanoid	1	1.000	-	-		X1565
TreeFam	1	0.960	-	-
	12	11.680