Protein Alignment Vha68-2 and ATP6V1A

DIOPT Version :9

• Sequence 1: NP_001246015.1
• Gene: Vha68-2 / 45012
• FlyBaseID: FBgn0263598
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001681.2
• Gene: ATP6V1A / 523
• HGNCID: 851
• Length: 617
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 513/614 - (83%)
• Similarity: 566/614 - (92%)
• Gaps: 1/614 - (0%)

  Fly     2 SNLKRFDDEERESKYGRVFAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYE 66
            |.|.:..||::||.:|.|..||||||||..|:|:|||||||||:.||||||||||||||||||||
Human     4 SKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYE 68

  Fly    67 ETSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINELTESIYIPKGVNVPSLSRVASW 131
            |||||:||||||||||||||||||||||:|||||||||.||:..|:|||||:||||.:|||...|
Human    69 ETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPRGVNVSALSRDIKW 133

  Fly   132 EFNPL-NVKVGSHITGGDLYGLVHENTLVKHKMIVNPRAKGTVRYIAPSGNYKVDDVVLETEFDG 195
            :|.|. |::|||||||||:||:|.||:|:|||:::.||.:|||.||||.|||...|||||.||:|
Human   134 DFTPCKNLRVGSHITGGDIYGIVSENSLIKHKIMLPPRNRGTVTYIAPPGNYDTSDVVLELEFEG 198

  Fly   196 EITKHTMLQVWPVRQPRPVTEKLPANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAL 260
            ...|.||:|||||||.|||||||||||||||||||||:|||||||||||||||||||||||||:|
Human   199 VKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSL 263

  Fly   261 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELSVEIDGVTESIMKRTALVANTSNMPVAAREASIY 325
            |||||||||||||||||||||||||||||||::|:||..||||||||||||||||||||||||||
Human   264 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIY 328

  Fly   326 TGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 390
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Human   329 TGITLSEYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 393

  Fly   391 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYM 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Human   394 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYM 458

  Fly   456 RALDDFYDKNFPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKITLEVAKLLKDDFLQQN 520
            ||||::|||:|.||||||||.||||||||||:||||||||||||||||||||||||:||||||||
Human   459 RALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQN 523

  Fly   521 SYSSYDRFCPFYKTVGMLRNIIDFYDMARHSVESTAQSENKITWNVIREAMGNIMYQLSSMKFKD 585
            .|:.||||||||||||||.|:|.||||||.:||:||||:|||||::|||.||:|:|:||||||||
Human   524 GYTPYDRFCPFYKTVGMLSNMIAFYDMARRAVETTAQSDNKITWSIIREHMGDILYKLSSMKFKD 588

  Fly   586 PVKDGEAKIKADFEQLHEDLQQAFRNLED 614
            |:||||||||:|:.||.||:|.|||:|||
Human   589 PLKDGEAKIKSDYAQLLEDMQNAFRSLED 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-2	NP_001246015.1	V-ATPase_V1_A	16..606	CDD:273411	500/590 (85%)
ATP6V1A	NP_001681.2	V-ATPase_V1_A	17..609	CDD:273411	500/591 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147695
Domainoid	1	1.000	441	1.000	Domainoid score	I550
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1033	1.000	Inparanoid score	I270
Isobase	1	0.950	-	0	Normalized mean entropy	S546
OMA	1	1.010	-	-		QHG60789
OrthoDB	1	1.010	-	-		D160349at33208
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm40895
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	LDO	PTHR43607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1628
SonicParanoid	1	1.000	-	-		X1565
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750