DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha68-2 and atp6v1aa

DIOPT Version :9

Sequence 1:	NP_001246015.1	Gene:	Vha68-2 / 45012	FlyBaseID:	FBgn0263598	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_957429.1	Gene:	atp6v1aa / 394110	ZFINID:	ZDB-GENE-040426-1143	Length:	617	Species:	Danio rerio

Alignment Length:	614	Identity:	513/614 - (83%)
Similarity:	568/614 - (92%)	Gaps:	1/614 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNLKRFDDEERESKYGRVFAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYE 66
            |.|.:..||||||::|.|..||||||||.:|:|:|||||||||:.||||||||||||||||||||
Zfish     4 SKLPKIRDEERESQFGYVHGVSGPVVTASSMAGAAMYELVRVGHSELVGEIIRLEGDMATIQVYE 68

  Fly    67 ETSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINELTESIYIPKGVNVPSLSRVASW 131
            |||||.||||||||||||||||||||||||||||||||||||:||:|||||:|||:.:|:|...|
Zfish    69 ETSGVCVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINDLTQSIYIPRGVNIGALNRDLKW 133

  Fly   132 EFNPL-NVKVGSHITGGDLYGLVHENTLVKHKMIVNPRAKGTVRYIAPSGNYKVDDVVLETEFDG 195
            :|.|: |::||||:||||:||||:||:|:|||:::.||::|||.|:||.|||.|.|||||.||:|
Zfish   134 DFTPINNLRVGSHVTGGDIYGLVNENSLIKHKLMLPPRSRGTVTYVAPPGNYDVSDVVLELEFEG 198

  Fly   196 EITKHTMLQVWPVRQPRPVTEKLPANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAL 260
            ...|.||:|||||||.|||||||||||||||||||||:|||||||||||||||||||||||||:|
Zfish   199 VKEKFTMVQVWPVRQVRPVTEKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSL 263

  Fly   261 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELSVEIDGVTESIMKRTALVANTSNMPVAAREASIY 325
            |||||||||||||||||||||||||||||||::|:.|..||||||||||||||||||||||||||
Zfish   264 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELTMEVGGKVESIMKRTALVANTSNMPVAAREASIY 328

  Fly   326 TGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   329 TGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 393

  Fly   391 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYM 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||.
Zfish   394 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYT 458

  Fly   456 RALDDFYDKNFPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKITLEVAKLLKDDFLQQN 520
            ||||::|||:|.||||||||.|||||.||||:||||||||||||||||||||||||:||||||||
Zfish   459 RALDEYYDKHFQEFVPLRTKAKEILQGEEDLAEIVQLVGKASLAETDKITLEVAKLIKDDFLQQN 523

  Fly   521 SYSSYDRFCPFYKTVGMLRNIIDFYDMARHSVESTAQSENKITWNVIREAMGNIMYQLSSMKFKD 585
            .|:.||||||||||||:|.|:|.|||:|||:||:||||:|||||..|||.||.|:|::|||||||
Zfish   524 GYTPYDRFCPFYKTVGILSNMIAFYDLARHAVETTAQSDNKITWAQIREHMGEILYRISSMKFKD 588

  Fly   586 PVKDGEAKIKADFEQLHEDLQQAFRNLED 614
            |||:||||||||:.||.||:|.:||.|||
Zfish   589 PVKEGEAKIKADYAQLLEDMQNSFRTLED 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-2	NP_001246015.1	V-ATPase_V1_A	16..606	CDD:273411	499/590 (85%)
atp6v1aa	NP_957429.1	V-ATPase_V1_A	17..609	CDD:273411	499/591 (84%)
		ATP-synt_ab_N	21..83	CDD:280947	52/61 (85%)
		V_A-ATPase_A	85..457	CDD:238554	322/371 (87%)
		ATP-synt_ab_C	475..617	CDD:278722	111/141 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581525
Domainoid	1	1.000	440	1.000	Domainoid score	I526
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1044	1.000	Inparanoid score	I258
OMA	1	1.010	-	-		QHG60789
OrthoDB	1	1.010	-	-		D160349at33208
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		mtm6576
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	O	PTHR43607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1565
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770