DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha68-2 and vma1

DIOPT Version :9

Sequence 1:	NP_001246015.1	Gene:	Vha68-2 / 45012	FlyBaseID:	FBgn0263598	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_593425.1	Gene:	vma1 / 2541660	PomBaseID:	SPAC343.05	Length:	619	Species:	Schizosaccharomyces pombe

Alignment Length:	614	Identity:	401/614 - (65%)
Similarity:	504/614 - (82%)	Gaps:	10/614 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NLKRFDDEERESKYGRVFAVSGPVVTAEAMSGSAMYELVRVGYYELVGEIIRLEGDMATIQVYEE 67
            :||.:|  |.|::||.:|:||||||.|..|.|.:||||||||:.|||||:||:..|..|||||||
pombe    14 SLKNYD--EHENRYGSIFSVSGPVVVAANMLGCSMYELVRVGHEELVGEVIRIHQDKCTIQVYEE 76

  Fly    68 TSGVTVGDPVLRTGKPLSVELGPGIMGSIFDGIQRPLKDINELTESIYIPKGVNVPSLSRVASWE 132
            |||:||||||.|||||||||||||:..:|:||||||||.|.:.::|||||:|:|..||:|...|:
pombe    77 TSGLTVGDPVQRTGKPLSVELGPGLAETIYDGIQRPLKQIFDKSQSIYIPRGINTESLNREHKWD 141

  Fly   133 FNP-LNVKVGSHITGGDLYGLVHENTLVK-HKMIVNPRAKGTVRYIAPSGNYKVDDVVLETEFDG 195
            |.| .::::|.|::|||::|.|.||:|.. ||:::.|||:|||.|||.:|:|.||:.:||.||:|
pombe   142 FTPNKDLRIGDHVSGGDVFGSVFENSLFNDHKIMLPPRARGTVTYIAEAGSYHVDEKLLEVEFNG 206

  Fly   196 EITKHTMLQVWPVRQPRPVTEKLPANHPLLTGQRVLDSLFPCVQGGTTAIPGAFGCGKTVISQAL 260
            :....:||..||||..|||.:.|.||.||||||||||:|:|||||||||||||||||||||||:|
pombe   207 KKHSFSMLHTWPVRAARPVADNLTANQPLLTGQRVLDALYPCVQGGTTAIPGAFGCGKTVISQSL 271

  Fly   261 SKYSNSDVIIYVGCGERGNEMSEVLRDFPELSVEIDGVTESIMKRTALVANTSNMPVAAREASIY 325
            |||||||:|:|||||||||||:|||.|||||:::|:|..|.|||||.||||||||||||||||||
pombe   272 SKYSNSDLIVYVGCGERGNEMAEVLMDFPELTIDINGKPEPIMKRTTLVANTSNMPVAAREASIY 336

  Fly   326 TGITLSEYFRDMGYNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRVK 390
            |||||:||:||.|.||||||||||||||||||||||||||||||||||||||:||||||||||.:
pombe   337 TGITLAEYYRDQGKNVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLASFYERAGRAR 401

  Fly   391 CLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINWLISYSKYM 455
            |||:|:|||:||||||||||||||||||||||||||||||||||||||||||||||..:|||||:
pombe   402 CLGSPDREGTVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSINTSLSYSKYI 466

  Fly   456 RALDDFYDKNFPEFVPLRTKVKEILQEEEDLSEIVQLVGKASLAETDKITLEVAKLLKDDFLQQN 520
            .||..:|::..|.|..||.::|:|:|:|:.:.||:|||||::|:||||:||::|.::|:||||||
pombe   467 NALQPWYEERVPGFNTLRDQIKQIIQQEDSMLEIIQLVGKSALSETDKVTLDIAGIIKNDFLQQN 531

  Fly   521 SYSSYDRFCPFYKTVGMLRNIIDFYDMARHSVESTAQSENKITWNVIREAMGNIMYQLSSMKFKD 585
            .||.|||.||.|||..|:||:|.:|..|:.:||:     ..:.|:.|:|:..:|.|:|:||||::
pombe   532 GYSDYDRCCPLYKTYHMMRNMIAYYTKAKSAVET-----GSVPWSKIKESTSDIFYELTSMKFEN 591

  Fly   586 PVKDGEAKIKADFEQLHEDLQQAFRNLED 614
            | .:||.:|...:|.||:.::..|..|.:
pombe   592 P-NEGEKEIVEHYETLHKKIEDKFHTLTE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha68-2	NP_001246015.1	V-ATPase_V1_A	16..606	CDD:273411	394/591 (67%)
vma1	NP_593425.1	V-ATPase_V1_A	24..611	CDD:273411	394/592 (67%)
		ATP-synt_ab_N	28..90	CDD:280947	43/61 (70%)
		V_A-ATPase_A	92..465	CDD:238554	276/372 (74%)
		ATP-synt_ab_C	483..619	CDD:278722	65/141 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	408	1.000	Domainoid score	I94
eggNOG	1	0.900	-	-		E1_COG1155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I62
OMA	1	1.010	-	-		QHG60789
OrthoFinder	1	1.000	-	-		FOG0001869
OrthoInspector	1	1.000	-	-		otm47164
orthoMCL	1	0.900	-	-		OOG6_100902
Panther	1	1.100	-	-	LDO	PTHR43607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1628
SonicParanoid	1	1.000	-	-		X1565
TreeFam	1	0.960	-	-
	13	12.860