Protein Alignment Tom40 and TOMM40L

DIOPT Version :9

• Sequence 1: NP_001259313.1
• Gene: Tom40 / 44978
• FlyBaseID: FBgn0016041
• Length: 344
• Species: Drosophila melanogaster
• Sequence 2: NP_115550.2
• Gene: TOMM40L / 84134
• HGNCID: 25756
• Length: 308
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 134/326 - (41%)
• Similarity: 193/326 - (59%)
• Gaps: 24/326 - (7%)

  Fly    21 LGLQEPAPLPSNSGSLTESSSSAEGLDSLAAAKDAALENPGTVEELHKKCKDIQAITFEGAKIML 85
            |||.....||..|                 ..::..|.|||:.:|||:.|||:.....||.|:::
Human     5 LGLAPMGTLPRRS-----------------PRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVV 52

  Fly    86 NKGLSNHFQVSHTINMSNVVPSGYRFGATYVGTKEFSPTEAFPVLLGDIDPAGNLNANVIHQFSA 150
            ||.||:||||:|||:||.:...||...|.|.|..:.||||.||.::||:|.:|:|||.|:...:.
Human    53 NKVLSSHFQVAHTIHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAE 117

  Fly   151 RLRCKFASQIQESKVVASQLTTDYRGSDYTLSLTVANPSIFTNSGVVVGQYLQSVTPALALGSEL 215
            |||.|...|.|::|.:..|...:|||.|||.:||:.||.:...|.::|..:|||:|..|.||.||
Human   118 RLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGEL 182

  Fly   216 AYQFGPNVPGRQIAIMSVVGRYTAGSSVWSGTL--GQSGLHVCYYQKASDQLQIGAEVETSLRMQ 278
            .|.   ..||.:.||:::.|:|:|..  |..||  |..|.|..||.:|::|:|:|.|.|.:.|:|
Human   183 VYH---RRPGEEGAILTLAGKYSAVH--WVATLNVGSGGAHASYYHRANEQVQVGVEFEANTRLQ 242

  Fly   279 ESVATLAYQIDLPKANLVFRGGIDSNWQIFGVLEKRLAPLPFTLALSGRMNHVKNNFRLGCGLMI 343
            ::..:..|.:.||:||:||||.:||||.:..||||::.|||.||||...:||.:|.|..|..:.:
Human   243 DTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFHCGFSITV 307

  Fly   344 G 344
            |
Human   308 G 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tom40	NP_001259313.1	Porin3_Tom40	57..344	CDD:132766	127/288 (44%)
TOMM40L	NP_115550.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		9/40 (23%)
		Porin3_Tom40	24..308	CDD:132766	127/288 (44%)
		Required for mitochondrial targeting. /evidence=ECO:0000250	281..308		12/26 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156360
Domainoid	1	1.000	321	1.000	Domainoid score	I1229
eggNOG	1	0.900	-	-		E1_KOG3296
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2314
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55758
OrthoDB	1	1.010	-	-		D1346842at2759
OrthoFinder	1	1.000	-	-		FOG0001620
OrthoInspector	1	1.000	-	-		mtm8554
orthoMCL	1	0.900	-	-		OOG6_101593
Panther	1	1.100	-	-	O	PTHR10802
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1729
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770