DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom40 and Tomm40

DIOPT Version :9

Sequence 1:	NP_001259313.1	Gene:	Tom40 / 44978	FlyBaseID:	FBgn0016041	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001103218.1	Gene:	Tomm40 / 53333	MGIID:	1858259	Length:	361	Species:	Mus musculus

Alignment Length:	365	Identity:	180/365 - (49%)
Similarity:	236/365 - (64%)	Gaps:	25/365 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNVLAASS---GAPGSGASNLGLGLQEPAP------LPSNSGSLTESSSSAEGLD--------- 47
            |||||||||   |.|.....:| :||..|.|      ||...|.|...||:..|.:
Mouse     1 MGNVLAASSPPAGPPPPPTPSL-VGLPPPPPSPPGFTLPPLGGGLGTGSSTGRGSERTPGAAASG 64

  Fly    48 SLAAAKDAA---LENPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGY 109
            :.||::|.:   |.||||.||.|:|||::..:..||.|:.:||||||.|||:||:.:..:..|.|
Mouse    65 AAAASEDGSCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNY 129

  Fly   110 RFGATYVGTKEFSPTEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDY 174
            .||.||||||:.|||||||||:||:|.:|:|||.||||.|..||.|.|.|.|:||.|..|:..:|
Mouse   130 HFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEY 194

  Fly   175 RGSDYTLSLTVANPSIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTA 239
            ||||:|.::|:.||.:...||::|..||||:||.||||.||.|.   ..||.:..:||:.|:||.
Mouse   195 RGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYH---RRPGEEGTVMSLAGKYTL 256

  Fly   240 GSSVWSGTLGQSGLHVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSN 304
            .:.:.:.||||:|:|..||.|||||||:|.|.|.|.|||::.|:..||:||||||.:|:|.::||
Mouse   257 NNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSN 321

  Fly   305 WQIFGVLEKRLAPLPFTLALSGRMNHVKNNFRLGCGLMIG 344
            |.:...|||:|.|||.||:|...:||.||.|..|.||.||
Mouse   322 WIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom40	NP_001259313.1	Porin3_Tom40	57..344	CDD:132766	152/286 (53%)
Tomm40	NP_001103218.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		26/72 (36%)
Tomm40	NP_001103218.1	Porin3_Tom40	77..361	CDD:132766	152/286 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846760
Domainoid	1	1.000	313	1.000	Domainoid score	I1301
eggNOG	1	0.900	-	-		E1_KOG3296
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H101105
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2368
Isobase	1	0.950	-	0	Normalized mean entropy	S1946
OMA	1	1.010	-	-		QHG55758
OrthoDB	1	1.010	-	-		D1346842at2759
OrthoFinder	1	1.000	-	-		FOG0001620
OrthoInspector	1	1.000	-	-		mtm8783
orthoMCL	1	0.900	-	-		OOG6_101593
Panther	1	1.100	-	-	LDO	PTHR10802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2855
SonicParanoid	1	1.000	-	-		X1729
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750