DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom40 and tomm40l

DIOPT Version :9

Sequence 1:	NP_001259313.1	Gene:	Tom40 / 44978	FlyBaseID:	FBgn0016041	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_998124.1	Gene:	tomm40l / 405895	ZFINID:	ZDB-GENE-040426-2319	Length:	338	Species:	Danio rerio

Alignment Length:	352	Identity:	165/352 - (46%)
Similarity:	226/352 - (64%)	Gaps:	22/352 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNVLAASSGA---PGSGASNL-----GLGLQEPAPLPSNSGSLTESSSSAEGLDSLAAAKDAAL 57
            ||:|||||:.:   ||.||..|     |..:...:|:.:.|.|.|....:           :..|
Zfish     1 MGSVLAASAPSPPPPGPGAPGLVSVPPGFTMPPVSPVSAPSSSPTGQQDT-----------EPPL 54

  Fly    58 ENPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGYRFGATYVGTKEFS 122
            .|||..||.|:|||::..:..||.::.:||||||||||:||:.:|....|.|||||||||||:..
Zfish    55 PNPGGFEECHRKCKEVFPVQMEGVRLTVNKGLSNHFQVNHTVLLSTQADSSYRFGATYVGTKQTG 119

  Fly   123 PTEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDYRGSDYTLSLTVAN 187
            |.|||||::||:|..|:|||.||||.:.::|.||..|.|:.|.|..|..|:::|.|:|.::|..|
Zfish   120 PGEAFPVMVGDMDNTGSLNAQVIHQITDKVRSKFVFQTQQQKFVNWQGDTEFKGEDFTAAVTFGN 184

  Fly   188 PSIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTAGSSVWSGTLGQSG 252
            |.:...||:||..||||||.:||||.||.|.   ..||.:..:||:.||||..:.:.:.|||.:|
Zfish   185 PDVLMGSGIVVAHYLQSVTSSLALGGELVYH---RRPGEEGTVMSLAGRYTGSNFIATLTLGGAG 246

  Fly   253 LHVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSNWQIFGVLEKRLAP 317
            :|..||.||:||||:|.|.|.|.|||::..|..||:|:|||||||:|.:||||.:...|||:|.|
Zfish   247 VHASYYHKANDQLQVGVEYEVSTRMQDTSVTFGYQLDVPKANLVFKGSLDSNWVVGANLEKKLQP 311

  Fly   318 LPFTLALSGRMNHVKNNFRLGCGLMIG 344
            ||.:||||..::|.|:.|:.|.|:.||
Zfish   312 LPLSLALSAYLDHRKHKFQCGFGITIG 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom40	NP_001259313.1	Porin3_Tom40	57..344	CDD:132766	146/286 (51%)
tomm40l	NP_998124.1	Porin3_Tom40	54..338	CDD:132766	146/286 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591969
Domainoid	1	1.000	313	1.000	Domainoid score	I1271
eggNOG	1	0.900	-	-		E1_KOG3296
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2430
OMA	1	1.010	-	-		QHG55758
OrthoDB	1	1.010	-	-		D1346842at2759
OrthoFinder	1	1.000	-	-		FOG0001620
OrthoInspector	1	1.000	-	-		mtm6454
orthoMCL	1	0.900	-	-		OOG6_101593
Panther	1	1.100	-	-	O	PTHR10802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2855
SonicParanoid	1	1.000	-	-		X1729
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800