DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom40 and Tomm40l

DIOPT Version :9

Sequence 1:	NP_001259313.1	Gene:	Tom40 / 44978	FlyBaseID:	FBgn0016041	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001076807.1	Gene:	Tomm40l / 304971	RGDID:	1562006	Length:	308	Species:	Rattus norvegicus

Alignment Length:	294	Identity:	126/294 - (42%)
Similarity:	186/294 - (63%)	Gaps:	7/294 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 KDAALENPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGYRFGATYVG 117
            ::..|.|||:.:|||:.|||:.....||.|:::||.||:||||:||::||.:...||.....|.|
  Rat    20 REEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHTAYAG 84

  Fly   118 TKEFSPTEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDYRGSDYTLS 182
            ..:.||||.||.::||:|.:|:|||.|:...:.|||.|...|.|::|.:..|...:|||.|||.:
  Rat    85 DWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTAT 149

  Fly   183 LTVANPSIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTAGSSVWSGT 247
            ||:.||.:...|.::|..:|||:|..|.||.||.|.   ..||.:.||:::.|:|:|  ..|..|
  Rat   150 LTLGNPDLIGESVIMVAHFLQSITHRLVLGGELVYH---RRPGEEGAILTLAGKYSA--LHWVAT 209

  Fly   248 L--GQSGLHVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSNWQIFGV 310
            |  |..|.|..||.||::|:|:|.|.|.:.|:|::..:..|.:.||:|::||||.:||||.:..|
  Rat   210 LNVGSGGAHASYYHKANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQADMVFRGLVDSNWCVGAV 274

  Fly   311 LEKRLAPLPFTLALSGRMNHVKNNFRLGCGLMIG 344
            |||::.|||.||||...:||.:|.|..|..:.:|
  Rat   275 LEKKMRPLPVTLALGAFLNHWRNRFHCGFSITVG 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom40	NP_001259313.1	Porin3_Tom40	57..344	CDD:132766	125/288 (43%)
Tomm40l	NP_001076807.1	Porin3_Tom40	24..308	CDD:132766	125/288 (43%)
Tomm40l	NP_001076807.1	Required for mitochondrial targeting. /evidence=ECO:0000269\|PubMed:17437969	281..308		12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350292
Domainoid	1	1.000	312	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3296
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2317
OMA	1	1.010	-	-		QHG55758
OrthoDB	1	1.010	-	-		D1346842at2759
OrthoFinder	1	1.000	-	-		FOG0001620
OrthoInspector	1	1.000	-	-		mtm9030
orthoMCL	1	0.900	-	-		OOG6_101593
Panther	1	1.100	-	-	O	PTHR10802
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1729
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770