DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom40 and tomm-40

DIOPT Version :9

Sequence 1:	NP_001259313.1	Gene:	Tom40 / 44978	FlyBaseID:	FBgn0016041	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_495912.1	Gene:	tomm-40 / 174431	WormBaseID:	WBGene00007686	Length:	301	Species:	Caenorhabditis elegans

Alignment Length:	287	Identity:	141/287 - (49%)
Similarity:	197/287 - (68%)	Gaps:	3/287 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 NPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGYRFGATYVGTKEFSP 123
            |||:.||||:|.:|:....|||||:|:|||||:|||||||:::| .:.:|||||||||||.:..|
Worm    17 NPGSYEELHRKARDVFPTCFEGAKLMVNKGLSSHFQVSHTLSLS-AMNTGYRFGATYVGTNQVGP 80

  Fly   124 TEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDYRGSDYTLSLTVANP 188
            .||:|:||||.|..||..|.::||... .|.|...|||:.|:..:|.|.:.:|...||.||:||.
Worm    81 AEAYPILLGDTDVNGNTTATILHQLGI-YRTKLQGQIQQGKLAGAQATIERKGRLSTLGLTLANI 144

  Fly   189 SIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTAGSSVWSGTLGQSGL 253
            .:...:|::|||:|:.:||.|.:|:|:.||:|.|:||.||:::|...||||...:.:.|||.||:
Worm   145 DLVNEAGILVGQFLRRLTPRLDVGTEMVYQYGKNIPGGQISVLSYAARYTANHFIAAATLGASGV 209

  Fly   254 HVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSNWQIFGVLEKRLA-P 317
            |:.||.|.::.|..|.|.|.:..:.|:|.|||||.:||:..:..|...|:||.:.||.||||: .
Worm   210 HLTYYHKQNENLAFGVEFECNANVGEAVTTLAYQTELPEEGVTMRASFDTNWTVGGVFEKRLSQQ 274

  Fly   318 LPFTLALSGRMNHVKNNFRLGCGLMIG 344
            |||||||||.:||||...:.|.||:||
Worm   275 LPFTLALSGTLNHVKAAGKFGIGLIIG 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom40	NP_001259313.1	Porin3_Tom40	57..344	CDD:132766	139/285 (49%)
tomm-40	NP_495912.1	Porin3_Tom40	16..301	CDD:132766	139/285 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164180
Domainoid	1	1.000	282	1.000	Domainoid score	I872
eggNOG	1	0.900	-	-		E1_KOG3296
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H101105
Inparanoid	1	1.050	289	1.000	Inparanoid score	I1698
Isobase	1	0.950	-	0	Normalized mean entropy	S1946
OMA	1	1.010	-	-		QHG55758
OrthoDB	1	1.010	-	-		D1346842at2759
OrthoFinder	1	1.000	-	-		FOG0001620
OrthoInspector	1	1.000	-	-		otm14473
orthoMCL	1	0.900	-	-		OOG6_101593
Panther	1	1.100	-	-	LDO	PTHR10802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2855
SonicParanoid	1	1.000	-	-		X1729
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750