DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tom40 and TOMM40

DIOPT Version :9

Sequence 1:	NP_001259313.1	Gene:	Tom40 / 44978	FlyBaseID:	FBgn0016041	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_001122388.1	Gene:	TOMM40 / 10452	HGNCID:	18001	Length:	361	Species:	Homo sapiens

Alignment Length:	365	Identity:	189/365 - (51%)
Similarity:	239/365 - (65%)	Gaps:	25/365 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNVLAASS---GAPGSGASNLGLGLQEPAP------LPSNSGSL---TESSSSAEGLDSLA--- 50
            |||||||||   |.|...|..| :||..|.|      ||...|||   |.:|.|:|.....|
Human     1 MGNVLAASSPPAGPPPPPAPAL-VGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGAATAS 64

  Fly    51 ---AAKDAA---LENPGTVEELHKKCKDIQAITFEGAKIMLNKGLSNHFQVSHTINMSNVVPSGY 109
               ||:|.|   |.||||.||.|:|||::..|..||.|:.:||||||||||:||:.:|.:..|.|
Human    65 ASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNY 129

  Fly   110 RFGATYVGTKEFSPTEAFPVLLGDIDPAGNLNANVIHQFSARLRCKFASQIQESKVVASQLTTDY 174
            .||.||||||:.|||||||||:||:|.:|:|||.||||....||.|.|.|.|:||.|..|:..:|
Human   130 HFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEY 194

  Fly   175 RGSDYTLSLTVANPSIFTNSGVVVGQYLQSVTPALALGSELAYQFGPNVPGRQIAIMSVVGRYTA 239
            ||||:|.::|:.||.:...||::|..||||:||.||||.||.|.   ..||.:..:||:.|:||.
Human   195 RGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYH---RRPGEEGTVMSLAGKYTL 256

  Fly   240 GSSVWSGTLGQSGLHVCYYQKASDQLQIGAEVETSLRMQESVATLAYQIDLPKANLVFRGGIDSN 304
            .:.:.:.||||:|:|..||.|||||||:|.|.|.|.|||::..:..||:|||||||:|:|.:|||
Human   257 NNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDSN 321

  Fly   305 WQIFGVLEKRLAPLPFTLALSGRMNHVKNNFRLGCGLMIG 344
            |.:...|||:|.|||.||||...:||.||.|:.|.||.||
Human   322 WIVGATLEKKLPPLPLTLALGAFLNHRKNKFQCGFGLTIG 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tom40	NP_001259313.1	Porin3_Tom40	57..344	CDD:132766	156/286 (55%)
TOMM40	NP_001122388.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		29/70 (41%)
TOMM40	NP_001122388.1	Porin3_Tom40	77..361	CDD:132766	156/286 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156358
Domainoid	1	1.000	321	1.000	Domainoid score	I1229
eggNOG	1	0.900	-	-		E1_KOG3296
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H101105
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2314
Isobase	1	0.950	-	0	Normalized mean entropy	S1946
OMA	1	1.010	-	-		QHG55758
OrthoDB	1	1.010	-	-		D1346842at2759
OrthoFinder	1	1.000	-	-		FOG0001620
OrthoInspector	1	1.000	-	-		mtm8554
orthoMCL	1	0.900	-	-		OOG6_101593
Panther	1	1.100	-	-	LDO	PTHR10802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2855
SonicParanoid	1	1.000	-	-		X1729
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750