Protein Alignment Actn3 and MICALL2

DIOPT Version :10

• Sequence 1: NP_524801.1
• Gene: Actn3 / 44964
• FlyBaseID: FBgn0015008
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_891554.1
• Gene: MICALL2 / 79778
• HGNCID: 29672
• Length: 904
• Species: Homo sapiens
• Alignment Length: 100
• Identity: 26/100 - (26%)
• Similarity: 51/100 - (51%)
• Gaps: 2/100 - (2%)

  Fly   448 SLLRWCQERVKPY-GIPMYEFSASWISGRALCAIIHSYLPDLIDKTYLAKKKPEEVLAYGIKVAK 511
            :|.:||:::.:.| .:.:...:.|:..|.|.|||:|.:.||||:.:.|.|:...|......:||:
Human     6 ALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENNKLAFRVAE 70

  Fly   512 S-IGVSDSVDLIRELRQGRPNLEKIVDFVEELQGY 545
            . :|:...:|....:....|:...|:.:|.:...|
Human    71 EHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNY 105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn3	NP_524801.1	SMC_N	<13..277	CDD:481474
		CH_SF	443..540	CDD:469584	24/93 (26%)
MICALL2	NP_891554.1	Forms an intramolecular interaction with the C-terminal coiled coil domain keeping the protein in a closed conformation. /evidence=ECO:0000250	1..260		25/99 (25%)
		CH_MICALL2	2..107	CDD:409102	25/99 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..178
		LIM_Mical_like_1	188..241	CDD:188828
		PHA03247	<243..649	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..722
		Mediates targeting to the cell plasma membrane. /evidence=ECO:0000250	261..697
		Necessary and sufficient for interaction with actinins. /evidence=ECO:0000250	261..388
		Forms an intramolecular interaction with the N-terminal Calponin-homology and LIM zinc-binding domains-containing region keeping the protein in a closed conformation. /evidence=ECO:0000250	698..807
		bMERB_dom	743..872	CDD:463467
		Mediates interaction with RAB13 and is required for transition from the closed to the opened conformation. /evidence=ECO:0000250	807..903