Protein Alignment Actn3 and SMTNL2

DIOPT Version :10

• Sequence 1: NP_524801.1
• Gene: Actn3 / 44964
• FlyBaseID: FBgn0015008
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001108446.1
• Gene: SMTNL2 / 342527
• HGNCID: 24764
• Length: 461
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 99/465 - (21%)
• Similarity: 162/465 - (34%)
• Gaps: 112/465 - (24%)

  Fly   156 QRAAENRLAEKQDRIKALEECLAN-------CKFQLKNVNEQYQKLKKASNQLIRESNQIRPQKS 213
            ||..|.|:||.......|...:|:       .:.||:.:..|.:.|..||...........|...
Human    39 QRGVERRVAEAMRLAGPLARTVADLQRDNQRLQAQLERLTRQVEALGLASGMSPVPGTPGTPSPP 103

  Fly   214 WSVLVGRRKGRISTRT-------SFVWKSLKLDQSERETLMGLKKRLSEEKEIKLRAKTEMSKIR 271
            .:..|..|..|:.:..       |...:...||..|           :.|.|::   ||..|.|.
Human   104 PAPGVPDRAPRLGSARFASHATFSLSGRGQSLDHDE-----------ASESEMR---KTSNSCIM 154

  Fly   272 KAMDELCLGKGELQFG----LQNKSETDASKDTLVVIDKALSALSQYNTLKFPDCNFQLSRLMKS 332
            :...:...|.|:   |    .||.|..|..:...|    :||.                 ||...
Human   155 ENGHQPGAGPGD---GPPEIAQNFSAPDPPRPRPV----SLSL-----------------RLPHQ 195

  Fly   333 LYGSLTTIRDRWIRKISSA------------VEPTPSCLKSNTPSLPEPPLTVSFSTDLFWDKIY 385
            ...::|.:.||:..:.|:|            :.|:||  :..||..|.|....|..|.......|
Human   196 PVTAITRVSDRFSGETSAAALSPMSAATLGGLNPSPS--EVITPWTPSPSEKNSSFTWSVPSSGY 258

  Fly   386 KPCTQS----NPVMPNTSLIPVLPKKQPKSLQLTCEPSVQYKVASRSST-----TAPVPKYL--- 438
            ...|.|    :|.:......||.|  ||.::........:.:...||.|     .|...|.|
Human   259 GAVTASKHSNSPPLVTPPQSPVSP--QPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEK 321

  Fly   439 -------GKTFGDRRLS------------------LLRWCQERVKPY-GIPMYEFSASWISGRAL 477
                   ||..|:.|..                  ||.||:.:...| .:.:..||:||..|.|.
Human   322 WEQETAAGKGKGEARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAF 386

  Fly   478 CAIIHSYLPDLIDKTYLAKKKPEEVLAYGIKVAKSIGVSDSVDLIRELR-QGR-PNLEKIVDFVE 540
            ||::||:.||..|...|:..:.::.......:|:::...:.:..:.::. .|| |:...:..:|:
Human   387 CALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQ 451

  Fly   541 ELQGYLDMYD 550
            .|..:|..::
Human   452 SLYNHLRRFE 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn3	NP_524801.1	SMC_N	<13..277	CDD:481474	28/134 (21%)
		CH_SF	443..540	CDD:469584	25/117 (21%)
SMTNL2	NP_001108446.1	PRK09039	<8..>84	CDD:181619	11/44 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	87..193		27/143 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..248		7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..307		11/48 (23%)
		CH_SMTNL2	352..458	CDD:409110	25/105 (24%)