Protein Alignment Actn3 and SMTNL1

DIOPT Version :10

• Sequence 1: NP_524801.1
• Gene: Actn3 / 44964
• FlyBaseID: FBgn0015008
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001099035.2
• Gene: SMTNL1 / 219537
• HGNCID: 32394
• Length: 494
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 100/457 - (21%)
• Similarity: 175/457 - (38%)
• Gaps: 91/457 - (19%)

  Fly   151 QARKNQRA-AENRL-AEKQDRIKALEECLANCKFQLKNVNEQYQKLKKASNQLIRESNQIRPQKS 213
            ::.|.::| ||:.: ||.|.....|:|.....:.:.....:...:|||...:  :|...:..|:
Human    49 ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGE--KEETTVGSQE- 110

  Fly   214 WSVLVGRRKGRISTRTSFVWKSLKLDQSERETLMGLKKRLSEEKEIK----------------LR 262
               :.||::..         ||...:..|:|:.:..:|:.:||||.|                .:
Human   111 ---MTGRKEET---------KSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPK 163

  Fly   263 AKTEMSKIRKAMDELCLGKGELQFGLQNKS---ETDASKDTLVVIDKALS--------ALSQYNT 316
            |..|....:.|..|....:.|.....:.|:   |..|.....||.|:|.:        ..:::..
Human   164 ATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGA 228

  Fly   317 LKFPDCNFQLSRLMKSLYGSLTTIRDRWIRKISSAVEPTPSCLKSNTPSLPE--PPLTVSFSTDL 379
            .:..|...:.....::..||.:..:::       .||..|.......||.||  |........:|
Human   229 KEEADAKEEAEDAEEAEPGSPSEEQEQ-------DVEKEPEGGAGVIPSSPEEWPESPTGEGHNL 286

  Fly   380 FWDKIYKPCTQSNPVMPNTSL-----IPVLPKKQPKSLQLTCEPSVQYKVASRSSTTAP------ 433
            ..|.:...|..|....|:.|.     :|..|.:.|.|.:.. |.:.:.:|::.:....|
Human   287 STDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKK-EKAPERRVSAPARPRGPRAQNRK 350

  Fly   434 --VPKYLGKTFGDRRL----------------SLLRWCQERVKPY-GIPMYEFSASWISGRALCA 479
              |.|:.|...|...|                .||.||:...|.| .:.:..||:||.||.|.||
Human   351 AIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDIQNFSSSWSSGMAFCA 415

  Fly   480 IIHSYLPDLIDKTYL--AKKKPEEVLAYGI--KVAKSIGVSDSVDLIRELRQGRPNLEKIVDFVE 540
            :||.:.||..|...|  ||::....||:..  |:|....:.|..|::   |...|:.:.:..:::
Human   416 LIHKFFPDAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLDVDDMV---RLAVPDSKCVYTYIQ 477

  Fly   541 EL 542
            ||
Human   478 EL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actn3	NP_524801.1	SMC_N	<13..277	CDD:481474	29/143 (20%)
		CH_SF	443..540	CDD:469584	33/117 (28%)
SMTNL1	NP_001099035.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..348		62/321 (19%)
		2A1904	<19..278	CDD:273344	49/250 (20%)
		CH_SMTNL1	379..494	CDD:409109	33/104 (32%)
		Calmodulin-binding. /evidence=ECO:0000250	476..494		2/4 (50%)