Protein Alignment Eip93F and LCOR

DIOPT Version :9

• Sequence 1: NP_001097865.1
• Gene: Eip93F / 44936
• FlyBaseID: FBgn0264490
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001333445.1
• Gene: LCOR / 84458
• HGNCID: 29503
• Length: 1557
• Species: Homo sapiens
• Alignment Length: 1165
• Identity: 213/1165 - (18%)
• Similarity: 357/1165 - (30%)
• Gaps: 381/1165 - (32%)

  Fly   241 LYKLLTQRAAKMTSMDSMAAQLAQFSLLADFNLINSLASQQQQQQQQQIASAVTPTTSEVSAAAI 305
            :.:::.|.||:.||.:|....                .||....:.|.:..|...|||..:|...
Human     1 MQRMIQQFAAEYTSKNSSTQD----------------PSQPNSTKNQSLPKASPVTTSPTAATTQ 49

  Fly   306 SPALKDTPSPSVDAPLDLS-----SKPSPNSSISGDVKSVRA-CATPTPSGRRAYSEEDLSRALQ 364
            :|.|........|:||||:     |:||....:. |:.:.:: ||     |..:.|......:.|
Human    50 NPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVL-DLSTKKSPCA-----GSTSLSHSPGCSSTQ 108

  Fly   365 DVVANKLDARKSASQHHEQRSILDNRLFKMKHHDQEQ-----------DHDG-DELEDSNDDA-- 415
            ....|..:| |:...:::.:|.|:..:.|:..|.|:|           ...| ::|:.|:..|
Human   109 GNGENSTEA-KAVDSNNQSKSPLEKFMVKLCTHHQKQFIRVLNDLYTESQPGTEDLQPSDSGAMD 172

  Fly   416 ---------------------------EAEVD-----SNASTPVYPAEFARAQLRKLSHLSEHNG 448
                                       .|.||     |::.:|:              ||:|...
Human   173 VSTCNAGCAQLSTKHKEKDALCLDMKSSASVDLFVDSSDSHSPL--------------HLTEQTP 223

  Fly   449 SDLGEDVDRGSPKMGRH-------------PACGNASANQGAPPSIPLDANVLLHTLMLAAGIGA 500
            .....::   :|..||.             |...:.|.|..:..|  .....|..:...:.....
Human   224 KKPPPEI---NPVDGRENALTVVQKDSSELPTTKSNSINSSSVDS--FTPGYLTASNCSSVNFHH 283

  Fly   501 MPKLDETQTVG-DFIKGLLVANSG------GIMNEGLLNLLSASQENSNGNASLLLQQQQHQQHH 558
            :||:.|.||.| :....:.:...|      ..:.|.|:.:..|::.:..||..::.|:...:...
Human   284 IPKILEGQTTGQEQDTNVNICEDGKDHMQSSALVESLITVKMAAENSEEGNTCIIPQRNLFKALS 348

  Fly   559 QQHHQQ--QQQQQHVAAYRHRLPKSETPETNSSLDPNDASEDPILKIPSFKVSGPASSSSLSPGG 621
            ::....  .......|...:.|...:|| ....|:.|:..            :.|...:.|...|
Human   349 EEAWNSGFMGNSSRTADKENTLQCPKTP-LRQDLEANEQD------------ARPKQENHLHSLG 400

  Fly   622 --LVGGHHHPLNNNNSLSISNNSNHSSNSHRNGSNRSPHSASPMLAAAVAQGGYSAGNSLLTSSS 684
              .||.|.||       |.....:||.:...        ...||.|...|..|:|....:.||..
Human   401 RNKVGYHLHP-------SDKGQFDHSKDGWL--------GPGPMPAVHKAANGHSRTKMISTSIK 450

  Fly   685 SSIQKMMASNIQRQINEQSGQESLRNGNVSDCSSNNGGSSSLGYKKPSISVAKIIGGTDTSRFGA 749
            ::.:...||.:  :||:...|          |.                    ::
Human   451 TARKSKRASGL--RINDYDNQ----------CD--------------------VV---------- 473

  Fly   750 SPNLLSQQHHSAHHLTHQQQQQQLSAQEALGKGTRPKRGKYRNYDRDSLVEAVKAVQRGEMSVHR 814
               .:||.....|   .:.|:..||:::...|.|   ||.:.|.|...| ..|:.:.|...|..:
Human   474 ---YISQPITECH---FENQKSILSSRKTARKST---RGYFFNGDCCEL-PTVRTLARNLHSQEK 528

  Fly   815 ------AGSYYGVPHSTLEYKVKERH---LMRPRKREP-KPQPDLV------GLTGPANKLQLDK 863
                  |......|..||.... .||   :..||:..| :|..::.      |...|..:.|..:
Human   529 ASCSALASEAVFTPKQTLTIPA-PRHTVDVQLPREDNPEEPSKEITSHEEGGGDVSPRKEPQEPE 592

  Fly   864 L---KAGPHGGSKLSNALKNQNNQAAAAA------------AAAAAAAAAATPNGLKLPLFEAGP 913
            :   |..|:    ||::.:::...|::..            ....:..:|.|.:|:..|.....|
Human   593 VCPTKIKPN----LSSSPRSEETTASSLVWPLPAHLPEEDLPEGGSTVSAPTASGMSSPEHNQPP 653

  Fly   914 QALSFQPNMFWPQTNATNAYGLDFNRITEAMRNPQASNHHGLMKSAQDMVENVYDGII------- 971
            .||                  ||    ||.|..||..:   |:.|.:.....|.:.:|
Human   654 VAL------------------LD----TEEMSVPQDCH---LLPSTESFSGGVSEDVISRPHSPP 693

  Fly   972 -----RKTLQASEGNGSAAGNGSNGSNGNGHGH-------GHGHGHAL-LDQLLVKKTPLPFTNH 1023
                 .::.|.||...|..|.....|.|....:       ..|....| :|.||  |....||:.
Human   694 EIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAEVESGDTQELNVDPLL--KESSTFTDE 756

  Fly  1024 RNNDYAATCSSASGESVKRSGSPMGNYADIK---------------------------------- 1054
            ..::      :...|:....|...|...|:|
Human   757 NPSE------TEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEENLDKKKKGKKFPEASDR 815

  Fly  1055 --RERLSADSGG-------SSDEEHSASHINNNNSDLAHNKNKSGGGGGGGGNG----------- 1099
              |.:||..|..       |||...:...|....:..|....|.|..||....|
Human   816 CLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRSKKEGHPGGTTPKGLLPDSFHTETL 880

  Fly  1100 -------------------QTNGNGRSSRMTSRDDSETDASSLKSGE---------SGGQQ---- 1132
                               :..|.|..:|.|.::..:.:...|: ||         :.||.
Human   881 EDTEKPSVNERPSEKDAEQEGEGGGIITRQTLKNMLDKEVKELR-GEIFPSRDPITTAGQPLPGE 944

  Fly  1133 ------NHKMMDLNGGSSSSSHIKCESEAATGHHSPGHHTTSILHEKLAQIKAEQVDQAD 1186
                  ..||.:.|....|.| |.|:.:.......|||..|..:.|.:.::..|...|.|
Human   945 RLEIYVQSKMDEKNAHIPSES-IACKRDPEQAKEEPGHIPTQHVEEAVNEVDNENTQQKD 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eip93F	NP_001097865.1	HTH_psq	794..839	CDD:283007	11/53 (21%)
LCOR	NP_001333445.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		14/65 (22%)
		Interaction with nuclear receptors	53..57		1/3 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002368
OrthoInspector	1	1.000	-	-		otm41978
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21545
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3313
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	6.090