DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eip93F and Lcor

DIOPT Version :9

Sequence 1:	NP_001097865.1	Gene:	Eip93F / 44936	FlyBaseID:	FBgn0264490	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_038941616.1	Gene:	Lcor / 365462	RGDID:	1311704	Length:	1998	Species:	Rattus norvegicus

Alignment Length:	1253	Identity:	225/1253 - (17%)
Similarity:	381/1253 - (30%)	Gaps:	425/1253 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 STDMLHIVALERVAEECMGRRQWKHYQDKLTCSHLNIEEQQPIAIAGSEDEPSQYNHSSKEISQS 88
            :.||...:|.|::.:|        ..:|.......::||       |.:|..|...|...|:
  Rat   991 TVDMQLPIAGEQLLKE--------DTRDDPRKERTSLEE-------GDKDTSSAKEHQEPEV--- 1037

  Fly    89 NPNHCKTENHRLEQQHNGSQLLEEEDSENNQTSHDSSRTPTPGATSTPSPPPEPIDWRPSAKCNF 153
                |.|:|.|                       |.|.:|.||.| |||.|.
  Rat  1038 ----CLTKNER-----------------------DPSVSPRPGET-TPSSPA------------- 1061

  Fly   154 CVNGRLLTVNAQGKLVAESAATATSSSTSNSHIHQHDSDSNSSASLPHHISSSSSSNNNSSGNRA 218
            |:....|| |.....:.|.:...:|.:.|....|:.|....:|...|..:.:.
  Rat  1062 CLLPAALT-NEDPSEMPEGSTVVSSPTASVLSFHEQDQPPAASLLGPEEMQAQ------------ 1113

  Fly   219 RHIAAASARATPAAATPANSLELYKLLTQRAAKMTSMDSMAAQLAQFSLLADFNLINSLASQQQQ 283
                                 |.:.:||..:..:||.:..                ..|..:.|.
  Rat  1114 ---------------------ECHLVLTGGSIPLTSGEGS----------------EDLPWRPQF 1141

  Fly   284 QQQQQIASAVTPTTSEVSAAAISPALKDTPSPSVDAPLDLSSKPSPNSSISGDVKSVRACATPTP 348
            ..:..:....:|.:::.|           |:.::|.||.|.......||      |..|.|..||
  Rat  1142 SPETAVREGRSPCSADKS-----------PAMALDPPLSLELSEHDQSS------STEAEARDTP 1189

  Fly   349 SGRRAYSEEDLSRALQDVVANKLDARKSASQHHEQRSILDNRLFKMKHHDQEQDH--DGDELEDS 411
             |.....:..|......:|.::    |:.||  .:...:.:....::.||::..:  :.|..|.:
  Rat  1190 -GETLLLDGSLPLLESSIVTDE----KNPSQ--TEGGEVASGTGHLEAHDEDIKYSAENDPSEPN 1247

  Fly   412 NDDAEAEVDSNASTPVYPAEFARAQLRKLSHLSEHNGSDLGEDVDRGSPKMGRHPACGNASANQG 476
            :...|..||........|....|. ||  |.|.:.:.:|             |:|      .:||
  Rat  1248 SGSPEENVDKKKKAKKLPEASDRC-LR--SQLVDSSSAD-------------RYP------GSQG 1290

  Fly   477 APPSIPLDANVLLHTLMLAAGIGAMPKLDETQTVGDFIKGLLVANSGGIMNEGLLNLLSASQENS 541
                  ||:|.....:    .:.....:..::..||         .||:.:||       |..:|
  Rat  1291 ------LDSNAACSEV----NVSKNHAVKHSKREGD---------CGGVTSEG-------SVIDS 1329

  Fly   542 NGNASLLLQQQQHQQHHQQHHQQQQQQQHVAAYRHRLPKSETPETNSSLDPNDASEDPILKIPSF 606
            |...||...:......|....:.:|:.:.:...        |.:|..:|...:...:.....||
  Rat  1330 NHTDSLEDTENPGVSEHSSDEETKQEAEGLGVI--------TRQTVKNLLAKEVKREEGGTSPS- 1385

  Fly   607 KVSGPASSSSLSPGGLVGGH----------HHPLNN----NNSLSISNNSNH------------- 644
              |.||:.|..||...:|..          |.|.::    .:...:..|..|
  Rat  1386 --SDPATVSQPSPQDNLGTRVWSKIDEKDAHVPSDSIPCKRDPEQVKENPGHIVIQDTEAAVREV 1448

  Fly   645 --SSNSHRNGSNRSPHSASPMLAAAVAQGGYSAGNSLLTSSSSSIQKMMASNIQRQINEQSGQES 707
              ....|.:|:.|:|.|::   |.:.:|.|.:||...|              ::|.....|...:
  Rat  1449 DAEDTHHEDGAGRAPCSSA---AISASQSGDAAGPPKL--------------VRRPKRLPSSTYN 1496

  Fly   708 LRNGNVSDCSSNNGGSSSLGYKKPSISVAKIIGGTDTSRF----------------GASPNLLSQ 756
            ||                         .|..:|..||::.                ||||
  Rat  1497 LR-------------------------PAHCVGALDTAKMTSEKQVTQVNPAPKESGASP----- 1531

  Fly   757 QHHSAHHLTHQQQQQQLSAQEALGKGTRPK-RGKYRNYDRDSLVEAVKA----VQRGEMSVHRAG 816
               ||..|  .::.....|:|      :|| .|.....:...|:.:..|    ||:|.:.:.:..
  Rat  1532 ---SAESL--DEEDSDTVAEE------QPKFVGWCAEEENQELIASFNAQYLRVQKGWIQLEKET 1585

  Fly   817 SYYGVPHSTLEYKV-KERHLMRPRKREPKPQPDL-VGLTGPANKLQLDKLKAGPHGGSKLSNALK 879
            .    |.|....|. |.:.:.:.:||..|.:..| |....|...|.:...        ||||..|
  Rat  1586 Q----PTSRARSKSDKLKEIWKSKKRSRKCRGSLEVQKFSPVQMLFMTNF--------KLSNICK 1638

  Fly   880 NQNNQAAAAAAAAAAAAAAATPNGLKL---PLFEAGPQALSFQPNMFWPQTNATNAYGLDFNRIT 941
            .........:...........|..:.|   ||       ..:.|:..:|.:       |...|:.
  Rat  1639 WFLETTETRSLVIVKKLNTRLPGDIPLVKHPL-------QKYPPSTMYPSS-------LQAERLK 1689

  Fly   942 EAMRN-P---QASNHHGLMKSAQDMVENVYDGIIRKTLQASEGNGSAAGNGSNGSNGNGHGHGHG 1002
            :.::. |   .|.|:....|....:.||      .:.::...|:..:.|..|..|........|.
  Rat  1690 KHLKKFPGAIPARNNWKTQKLWAKLREN------PEQVEPDAGSDISLGPNSEDSVEEVRESRHS 1748

  Fly  1003 HGHALLDQLLVKKTPLPFTNHRNNDYAATCSSASGESVKRSGSPMGNYADIKRERLSADSGGSSD 1067
            |          ..|.||             :.||...:::..:..|.   ::.:||.:..||:|:
  Rat  1749 H----------PPTNLP-------------TPASTRILRKYSNIRGK---LRAQRLDSSVGGASE 1787

  Fly  1068 EEHSASHINNN---NSDLA-----------------------------------HNKNKSGGGGG 1094
            .:.....:..|   :..||                                   .||.|. ..|.
  Rat  1788 IKQGRKSVCINPLMSPKLALQVGADGFPVNPKRAERSKGRRGKQMPETLLKVEGQNKRKR-AEGS 1851

  Fly  1095 GGGNGQTNGNG-RSSRMTSRDDSETDASSLKSGESGGQQNHKM--------MDLNGGSSSSSHIK 1150
            |..:|:..|.. ::||:.|.      |..|.:.:...|.:.||        :...|...|....:
  Rat  1852 GTQDGKDKGPATKASRVLSA------AKKLAAKDRVNQLSKKMTLKENKVRVCRKGPGKSCPASR 1910

  Fly  1151 CESEAATGHHSPGHHTTS 1168
            .|.|.|  :..|||.|.:
  Rat  1911 KEKENA--NRRPGHPTAA 1926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eip93F	NP_001097865.1	HTH_psq	794..839	CDD:283007	9/49 (18%)
Lcor	XP_038941616.1	Herpes_BLLF1	<637..>917	CDD:282904
		Herpes_BLLF1	<781..1059	CDD:282904	25/113 (22%)
		DUF4553	1544..1996	CDD:405731	84/456 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002368
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000