Protein Alignment Hsp70Ba and HSPA1L

DIOPT Version :10

• Sequence 1: NP_731716.1
• Gene: Hsp70Ba / 44921
• FlyBaseID: FBgn0013277
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_005518.3
• Gene: HSPA1L / 3305
• HGNCID: 5234
• Length: 641
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 478/641 - (74%)
• Similarity: 556/641 - (86%)
• Gaps: 9/641 - (1%)

  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||:||||||
Human     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||::||.:..|||.|||:|:::|||||:.|.||||:|.|.|||||||||||:||||||:|
Human    73 KRLIGRKFNDPVVQADMKLWPFQVINEGGKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |..:|:|||||||||||||||||||||.|||||||||||||||||:||||||..:|||:||||||
Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDL 202

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262
            |||||||||||||:| :|||::|||||||||||||||||:|..||||||:|||:..|.||:||||
Human   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.|||||||||||:|.:|||:|:||.||||.::|||||||||||||.||:||||||.||||||.
Human   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKA 331

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            :|||||||||||||||||.|||::|:|::||.|||||||||||||||||||.||:|.|:||:||:
Human   332 KIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||||:||||||||.||:||..||.|||:.|:|||||||||.|||||||||||||||.||.|
Human   397 DVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRF 461

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            ||:|||||||||||||||||:||||||||:|.:.||||...|||.|||||||:.||:|||.:|||
Human   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITNDKGRLSKEEIERMVLDAEK 526

  Fly   523 YADEDEKHRQRITSRNALESYVYNVKQSV-EQAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEK 586
            |..|||..|::|.::||||||.:|:|..| ::...||:.|:|||.:||||||.:.||:.|..|||
Human   527 YKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDKCNELLSWLEVNQLAEK 591

  Fly   587 EEFDHKMEELARHCSPIMTKMHQQG-AGAAGGPGANCGQQAGGFGGYSGPTVEEVD 641
            :|||||.:||.:.|:||:||::|.| .|.|.|.|...|:.|      :|||:||||
Human   592 DEFDHKRKELEQMCNPIITKLYQGGCTGPACGTGYVPGRPA------TGPTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	476/639 (74%)
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		309/380 (81%)
		PTZ00009	4..641	CDD:240227	476/639 (74%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		91/114 (80%)