DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp70Ba and Hsph1

DIOPT Version :9

Sequence 1:	NP_731716.1	Gene:	Hsp70Ba / 44921	FlyBaseID:	FBgn0013277	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001011901.1	Gene:	Hsph1 / 288444	RGDID:	1311609	Length:	858	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	215/720 - (29%)
Similarity:	344/720 - (47%)	Gaps:	122/720 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|:|:|:....:.|.:.|.:|.|||:..:|.|||.::|....|.||..||||...:..|||.
  Rat     1 MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVS 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVE--YKGESKRFAPEEISSMVLTKMKE 126
            ..||..||.::||.|.::.::..:.:|  .:||   :|::  |..|...|:.|:|::|:|||:||
  Rat    66 SFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGG---VGIKVMYMDEDHLFSVEQITAMLLTKLKE 127

  Fly   127 TAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDK----NLK 187
            |||..|.:.:||.||:||::|.|::|::..||..|.|||.||::|:.||.||.||:.|    |..
  Rat   128 TAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAD 192

  Fly   188 GERNVLIF-DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDL 251
            .:..|::| |:|..:|.||....::|.| :|..||.|..|||::||.:||.|...|||.|||.|.
  Rat   193 EKPRVVVFVDMGHSSFQVSACAFNKGKL-KVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDA 256

  Fly   252 RSNPRALRRLRTAAERAKRTLSS-STEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPV 315
            :|..|||.||....|:.|:.:|| ||:..:.|:.....:|...|::|::||||||:|.:....|:
  Rat   257 KSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPL 321

  Fly   316 EKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSG 380
            ...:....:...::..|.:|||:||||.|:..:..|| ||:::.::|.|||||.|.|:|.||||
  Rat   322 HLLMEQTHLKTEEVSAIEIVGGATRIPAVKERIARFF-GKDVSTTLNADEAVARGCALQCAILS- 384

  Fly   381 DQSGKIQDVLLVDVAPLSLGI-------ETAGGVMTKLIERNCRIPCKQTKTF---------STY 429
             .:.|:::..:.|..|..:.:       ||.|  :.::..||...|..:..||         :.|
  Rat   385 -PAFKVREFSVTDAVPFPISLVWNHDSEETEG--VHEVFSRNHAAPFSKVLTFLRRGPFELEAFY 446

  Fly   430 SDNQ--------------PGVSIQVYEGERAMTK------------------------------- 449
            ||.|              ..||.| .:||::..|
  Rat   447 SDPQAVPYPEAKIGRFVVQNVSAQ-KDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSS 510

  Fly   450 ------------------------DNNALGT--------FDLSGIPPAPRGVPQIEVTFDLD-AN 481
                                    ||:..||        ...|..||:|....:.....|.| ||
  Rat   511 VEADMECPNQKPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEENKIPDADKAN 575

  Fly   482 GILNVSAKEMSTGKAKNITIK-----NDKGRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALE 541
            ........|....|.|.:.::     |...:|.:..::..:....|...:|:..::|..::||:|
  Rat   576 EKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVE 640

  Fly   542 SYVYNVKQSVEQAPAGK-LDEADKNSVLDKCNETIRWL-DSNTTAEKEEFDHKMEELARHCSPIM 604
            ..||..:..: ..|..| :.|.:....|....||..|| :......|:.:..|:|||.:..:|:.
  Rat   641 ECVYEFRDKL-CGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVK 704

  Fly   605 TKMHQ 609
            .:..:
  Rat   705 VRFQE 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	214/719 (30%)
Hsp70Ba	NP_731716.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	152/385 (39%)
Hsph1	NP_001011901.1	HSPH1_NBD	2..384	CDD:212689	152/386 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..585		12/84 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900