DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp70Ba and SPAC57A7.12

DIOPT Version :9

Sequence 1:	NP_731716.1	Gene:	Hsp70Ba / 44921	FlyBaseID:	FBgn0013277	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_593369.1	Gene:	SPAC57A7.12 / 2542131	PomBaseID:	SPAC57A7.12	Length:	566	Species:	Schizosaccharomyces pombe

Alignment Length:	546	Identity:	152/546 - (27%)
Similarity:	267/546 - (48%)	Gaps:	61/546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDAK 68
            |||..|...|.:...:.||.:::||::|||..||.:::...:...|..|:.|:..|..|:|.:.:
pombe    27 IGISFGNQNSSIAFNRDGKTDVLANEEGNRQIPSILSYHGDQEYHGVQARGQLVRNADNSVTNFR 91

  Fly    69 RLIGRKYDDPKIAEDMKHWPFKVVSDGGKP--KIGVEYKGES----KRFAPEEISSMVLTKMKET 127
            .|:|:.:|:  :.....|:....|:..|:.  ||.|:...||    |.....|.|...|.::.|:
pombe    92 DLLGKSHDE--LTLHHCHYSANPVNVEGQIGFKITVQEDEESDPKEKILTAHEASVRHLRRLTES 154

  Fly   128 AEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNV 192
            ||.:||..:...|::||.||.|:||:|.:.|.:.|||.||::|::|.|..||....:.:..::.|
pombe   155 AEDFLGTKVNGCVMSVPVYFTDAQRKALESAANEAGLPVLQLIHDPAAVILALMYSEEVLIDKTV 219

  Fly   193 LIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRA 257
            ::.:.|....:||:::: :|.|..:.::..|.:||||...:.||...|:||::|...|.|.|.|:
pombe   220 VVANFGATRSEVSVVSV-KGGLMTILASVHDENLGGEQLTDVLVNFFAKEFEKKNGIDPRKNARS 283

  Fly   258 LRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDA 322
            |.:||...|..||.||:.|.|:..:|:|.:|.||::.::|.|::...:.........|.:|:..|
pombe   284 LAKLRAQCEITKRVLSNGTTASAAVDSLADGIDFHSSINRLRYDLAASATLNRMADLVTEAVEKA 348

  Fly   323 KMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNL--------NLSINPDEAVAYGAAVQAAILS 379
            .|:...|.:::|.||::..||:.||::..|..:.:        .|.::|.|..|.|:.|||:::.
pombe   349 NMEPFDISEVILAGGASNTPKLTSLMESIFPEQTIIRSSSSVTPLQLDPSELTAIGSGVQASLIG 413

  Fly   380 GDQSGKI---QDVLLVDVAPLS--LGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQ 439
            ...:..|   .|..:|||..|:  :||......:| :.:....:|.:  ||....:..:....|.
pombe   414 HFDAADIAASTDAQVVDVPHLTAPIGINEGENFVT-IFDIETALPAR--KTVEVIAPKEGAAFIP 475

  Fly   440 VYEGERA--MTK-----------------------------DNNALGTFDLSGIPPAPRGVPQIE 473
            :||.||:  :||                             ....:.|..|..:.|..:    ||
pombe   476 IYEAERSVKVTKVEPEPIDEEEAFSDDEEEEPEEIKERIAIPKTLIATITLPDVSPNAK----IE 536

  Fly   474 VTFDLDANGILNVSAKEMSTGKAKNI 499
            :...:||.|.|..||:. ..||..|:
pombe   537 LVLQIDAEGKLTASARP-KDGKGTNV 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	152/546 (28%)
Hsp70Ba	NP_731716.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	119/388 (31%)
SPAC57A7.12	NP_593369.1	DnaK	22..554	CDD:223520	149/537 (28%)
SPAC57A7.12	NP_593369.1	ScSsz1p_like_NBD	25..410	CDD:212674	118/385 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900