DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp70Ba and sks2

DIOPT Version :9

Sequence 1:	NP_731716.1	Gene:	Hsp70Ba / 44921	FlyBaseID:	FBgn0013277	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_595438.1	Gene:	sks2 / 2540199	PomBaseID:	SPBC1709.05	Length:	613	Species:	Schizosaccharomyces pombe

Alignment Length:	587	Identity:	342/587 - (58%)
Similarity:	433/587 - (73%)	Gaps:	6/587 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |||||||||||||.|::...||||.||||.|||||:||||::|||:||.||||.|||||||||||
pombe     8 AIGIDLGTTYSCVAVWETANVEIIPNDQGARTTPSFVAFTETERLVGDAAKNQAAMNPRNTVFDA 72

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            ||||||:|:||:..:|:|||||||:.:.|.|.|.|.|.||.|:|..:|||:||||||||.:||.|
pombe    73 KRLIGRRYEDPETQKDIKHWPFKVIDNNGIPTIEVNYLGEKKQFTAQEISAMVLTKMKEISEAKL 137

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            .:.:..|||||||||:||||.||||||.|||||||||||||||||:|||||......:|||||||
pombe   138 NKRVEKAVITVPAYFSDSQRAATKDAGAIAGLNVLRIINEPTAAAIAYGLDAKSDKPKNVLIFDL 202

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262
            ||||||||:|.| :|.:|||.:||||||||||||||.||.|..:|||||.|.|:..:||||||||
pombe   203 GGGTFDVSLLKI-QGGVFEVLATAGDTHLGGEDFDNALVEHFIQEFKRKQKIDISDDPRALRRLR 266

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            :|.|||||.|||.|:.|:|:|:|..|.||.:.::|||||::.|..|:.|:.||.|.|.|:|:.|.
pombe   267 SACERAKRALSSVTQTTVEVDSLSNGIDFSSSITRARFEDINATTFKATIDPVAKVLKDSKVPKA 331

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGD-QSGKIQDVLL 391
            .:||||||||||||||||.|:.:||.|:.||.|||||||||||||||||:|:.. .|.|.||:||
pombe   332 DVHDIVLVGGSTRIPKVQRLVSDFFDGRALNKSINPDEAVAYGAAVQAAVLTNKADSDKTQDLLL 396

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGT 456
            :||.|||||:...|.|...:..||..||..:.:||:|.:|||..|:..||:|||....:|..||.
pombe   397 LDVVPLSLGVAMEGNVFGVVCPRNTPIPTIKKRTFTTVADNQTTVTFPVYQGERVNCAENEPLGE 461

  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521
            |.|:||||.|||..::|.||:|||||||.|:|.|.:||::.:|.|.|..|.||..:|..|:..|:
pombe   462 FQLTGIPPMPRGQAELEATFELDANGILKVTAVEKTTGRSAHIEITNSVGHLSSTKIQEMIENAD 526

  Fly   522 KYADEDEKHRQRITSRNALESYVYNVKQSV-EQAPAGKLDEADKNSV---LDKCNETIRWLDSNT 582
            |:..:|:...:::.:::.||||:.|::.:: |.....||...||:.:   |.:|...:...|:||
pombe   527 KFKQQDKDFAKKLEAKSQLESYISNIETTISEPNVMMKLKRGDKSKIEAQLAECMSQLELEDTNT 591

  Fly   583 TA 584
            .|
pombe   592 DA 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	342/587 (58%)
Hsp70Ba	NP_731716.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	256/375 (68%)
sks2	NP_595438.1	HSP70	8..613	CDD:278441	342/587 (58%)
		HSPA1-2_6-8-like_NBD	8..383	CDD:212675	256/375 (68%)
		BAR	<503..>603	CDD:299863	27/91 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.800