Protein Alignment Hsp70Ba and HSPA4L

DIOPT Version :9

• Sequence 1: NP_731716.1
• Gene: Hsp70Ba / 44921
• FlyBaseID: FBgn0013277
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001304310.1
• Gene: HSPA4L / 22824
• HGNCID: 17041
• Length: 870
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 193/709 - (27%)
• Similarity: 337/709 - (47%)
• Gaps: 111/709 - (15%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:.||:|:..|.|||:.
Human    32 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 96

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..|:|.||.:|||.:..:....|:::.. ..|...:.|.|..|.:.||.|:::.|:|.|:|||:|
Human    97 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 161

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN-----LKGE 189
            ..|.:.:.|.||::|::|.|::|::...|..:||||.||::||.||.|||||:.|.     .:..
Human   162 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPPLDEKP 226

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSN 254
            |||:..|:|...:.|.:...::|.| :|.:|..|.:|||.:||..||.:..:|||.|||.:::.|
Human   227 RNVVFIDMGHSAYQVLVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKEN 290

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|..:|::||:||:|||.|......|::..
Human   291 SRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAV 355

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            :..|.:.:..|..|.:|||:||||.|:..:.:||. |:::.::|.|||||.|.|:|.||||  .:
Human   356 MEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDISTTLNADEAVARGCALQCAILS--PA 417

  Fly   384 GKIQDVLLVDVAPLSL------GIETAGGVMTKLIERNCRIPCK-QTKTFS---TYSDNQPGVSI 438
            .|:::..:.|:.|.|:      ..|...|        .|.:.|| ....||   |:...:|....
Human   418 FKVREFSITDLVPYSITLRWKTSFEDGSG--------ECEVFCKNHPAPFSKVITFHKKEPFELE 474

  Fly   439 QVYEGERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVSA-------------- 488
            ..|.....:...:..:|:|.:..:.|...| ..:::|...::.:||.:|::
Human   475 AFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHS 539

  Fly   489 -------------------------------------------------------------KEMS 492
                                                                         :.:.
Human   540 DAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLK 604

  Fly   493 TGKAKNITIKNDKG---RLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVYNVKQSVEQA 554
            .||.|:|.:.....   :|.|..::..:....|...:|:..::|..::||:|.|||:.:..:...
Human   605 KGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTV 669

  Fly   555 PAGKLDEADKNSVLDKCNETIRWL-DSNTTAEKEEFDHKMEELARHCSPIMTKM--HQQ 610
            ....:...|.:.:.....:|..|| :......|:.:..|::||.::..||..|.  |::
Human   670 YEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEE 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ba	NP_731716.1	PTZ00009	2..641	CDD:240227	192/708 (27%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	141/382 (37%)
HSPA4L	NP_001304310.1	HSPA4L_NBD	33..415	CDD:212688	141/383 (37%)
		HSP70	34..725	CDD:278441	191/702 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900