DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Ba and Hspa8

DIOPT Version :9

Sequence 1:NP_731716.1 Gene:Hsp70Ba / 44921 FlyBaseID:FBgn0013277 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_112442.2 Gene:Hspa8 / 15481 MGIID:105384 Length:646 Species:Mus musculus


Alignment Length:643 Identity:482/643 - (74%)
Similarity:554/643 - (86%) Gaps:4/643 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFD 66
            ||:|||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||.|||||
Mouse     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFD 69

  Fly    67 AKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131
            |||||||::||..:..|||||||.||:|.|:||:.||||||:|.|.|||:||||||||||.||||
Mouse    70 AKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAY 134

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||:::|:||:||||||||||||||||||.|||||||||||||||||:||||||.:..||||||||
Mouse   135 LGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFD 199

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRL 261
            |||||||||||||::| :|||:||||||||||||||||:|.|...|||||:|||:..|.||:|||
Mouse   200 LGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL 263

  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDK 326
            |||.|||||||||||:|:||||:|:||.||||.::|||||||.|||||.||.||||||.|||:||
Mouse   264 RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDK 328

  Fly   327 GQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLL 391
            .||||||||||||||||:|.|||:||:||.||.||||||||||||||||||||||:|..:||:||
Mouse   329 SQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLL 393

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGT 456
            :||.||||||||||||||.||:||..||.|||:||:|||||||||.|||||||||||||||.||.
Mouse   394 LDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGK 458

  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521
            |:|:|||||||||||||||||:||||||||||.:.||||...|||.|||||||:.:|:|||.|||
Mouse   459 FELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAE 523

  Fly   522 KYADEDEKHRQRITSRNALESYVYNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTTAE 585
            ||..||||.|.:::|:|:||||.:|:|.:|| :...||:::.||..:||||||.|.|||.|.|||
Mouse   524 KYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKNQTAE 588

  Fly   586 KEEFDHKMEELARHCSPIMTKMHQQGAGAAGG-PGANCGQQAGGFGG-YSGPTVEEVD 641
            ||||:|:.:||.:.|:||:||::|...|..|| ||...|..|...|| .||||:||||
Mouse   589 KEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BaNP_731716.1 PTZ00009 2..641 CDD:240227 480/641 (75%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 304/375 (81%)
Hspa8NP_112442.2 PTZ00009 1..613 CDD:240227 464/608 (76%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 309/381 (81%)
Interaction with BAG1. /evidence=ECO:0000250 186..377 150/191 (79%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 92/114 (81%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646 15/31 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D288077at2759
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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