DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsp70Ba and Hspa5

DIOPT Version :9

Sequence 1:NP_731716.1 Gene:Hsp70Ba / 44921 FlyBaseID:FBgn0013277 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_001156906.1 Gene:Hspa5 / 14828 MGIID:95835 Length:655 Species:Mus musculus


Alignment Length:619 Identity:381/619 - (61%)
Similarity:486/619 - (78%) Gaps:13/619 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||||||||:::|:|||||||||||.|||||||| :.||||||.||||:..||.||||||
Mouse    32 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 96

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEY-KGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||.::||.:.:|:|..|||||....||.|.|:. .|::|.|||||||:|||||||||||||
Mouse    97 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 161

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            ||:.:|.||:||||||||:|||||||||.||||||:||||||||||:||||||. :||:|:|:||
Mouse   162 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 225

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRL 261
            |||||||||:||||.| :|||.:|.|||||||||||.|::.|..:.:|:|..||:|.:.||:::|
Mouse   226 LGGGTFDVSLLTIDNG-VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKL 289

  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDK 326
            |...|:|||.|||..:|.|||::.|||:||...::||:||||..||||:|::||:|.|.|:.:.|
Mouse   290 RREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKK 354

  Fly   327 GQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLL 391
            ..|.:||||||||||||:|.|::|||:||..:..|||||||||||||||.:|||||.  ..|::|
Mouse   355 SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQD--TGDLVL 417

  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGT 456
            :||.||:|||||.||||||||.||..:|.|:::.|||.|||||.|:|:||||||.:||||:.|||
Mouse   418 LDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGT 482

  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521
            |||:||||||||||||||||::|.||||.|:|::..||....|||.||:.||:..||:||||:||
Mouse   483 FDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAE 547

  Fly   522 KYADEDEKHRQRITSRNALESYVYNVKQSV--EQAPAGKLDEADKNSVLDKCNETIRWLDSNTTA 584
            |:|:||:|.::||.:||.||||.|::|..:  ::...|||...||.::.....|.|.||:|:..|
Mouse   548 KFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDA 612

  Fly   585 EKEEFDHKMEELARHCSPIMTKMHQQGAGAAGGP 618
            :.|:|..|.:||.....||::|::     .:|||
Mouse   613 DIEDFKAKKKELEEIVQPIISKLY-----GSGGP 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BaNP_731716.1 PTZ00009 2..641 CDD:240227 381/619 (62%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 250/376 (66%)
Hspa5NP_001156906.1 Required for interaction with KIAA1324. /evidence=ECO:0000250|UniProtKB:P11021 1..81 39/48 (81%)
HSP70 31..636 CDD:365808 378/607 (62%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 126..281 111/156 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 410..420 3/11 (27%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 421..501 58/79 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..655 4/15 (27%)
Prevents secretion from ER 652..655
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.810

Return to query results.
Submit another query.