Protein Alignment Hsp70Ab and KAR2

DIOPT Version :10

• Sequence 1: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_012500.3
• Gene: KAR2 / 853418
• SGDID: S000003571
• Length: 682
• Species: Saccharomyces cerevisiae
• Alignment Length: 619
• Identity: 377/619 - (60%)
• Similarity: 470/619 - (75%)
• Gaps: 10/619 - (1%)

  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDAK 68
            ||||||||||||.|.::||.||:||:||||.|||||||||.||||||.||||||.||:||:||.|
Yeast    53 IGIDLGTTYSCVAVMKNGKTEILANEQGNRITPSYVAFTDDERLIGDAAKNQVAANPQNTIFDIK 117

  Fly    69 RLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYLG 133
            ||||.||:|..:.:|:||.||.||:..|||.:.|..|||.|.|.|||||.|:|.|||:.||.|||
Yeast   118 RLIGLKYNDRSVQKDIKHLPFNVVNKDGKPAVEVSVKGEKKVFTPEEISGMILGKMKQIAEDYLG 182

  Fly   134 ESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDLG 198
            ..:|.||:||||||||:|||||||||.|||||||||:|||||||:||||||:.| |..::::|||
Yeast   183 TKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKSDK-EHQIIVYDLG 246

  Fly   199 GGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLRT 263
            |||||||:|:|:.| :|||::|:|||||||||||.::|..|...||:|:..|:..|.:||.:|:.
Yeast   247 GGTFDVSLLSIENG-VFEVQATSGDTHLGGEDFDYKIVRQLIKAFKKKHGIDVSDNNKALAKLKR 310

  Fly   264 AAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQ 328
            .||:|||.|||.....||||:..:|.|....::||:||||..|||:.||:||||.|.|:.::|..
Yeast   311 EAEKAKRALSSQMSTRIEIDSFVDGIDLSETLTRAKFEELNLDLFKKTLKPVEKVLQDSGLEKKD 375

  Fly   329 IHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVD 393
            :.|||||||||||||||.||:.:|.||..:..|||||||||||||||.:|||::.  ::|::|:|
Yeast   376 VDDIVLVGGSTRIPKVQQLLESYFDGKKASKGINPDEAVAYGAAVQAGVLSGEEG--VEDIVLLD 438

  Fly   394 VAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGTFD 458
            |..|:|||||.|||||.||:||..||.|:::.|||..||||.|.|:||||||||:||||.||.|:
Yeast   439 VNALTLGIETTGGVMTPLIKRNTAIPTKKSQIFSTAVDNQPTVMIKVYEGERAMSKDNNLLGKFE 503

  Fly   459 LSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEKY 523
            |:||||||||||||||||.|||||||.|||.:..|||:::|||.||||||:|.||||||.||||:
Yeast   504 LTGIPPAPRGVPQIEVTFALDANGILKVSATDKGTGKSESITITNDKGRLTQEEIDRMVEEAEKF 568

  Fly   524 ADEDEKHRQRITSRNALESYVFNVKQAVEQAPAGKLDEADKNSVLDKCNDTIRWLDSN-TTAEKE 587
            |.||...:.::.|||.||:|..::|..|......||:|.||.::||..||.:.|||.| .||..|
Yeast   569 ASEDASIKAKVESRNKLENYAHSLKNQVNGDLGEKLEEEDKETLLDAANDVLEWLDDNFETAIAE 633

  Fly   588 EFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGA 621
            :||.|.|.|::...||.:|::     .||.|.||
Yeast   634 DFDEKFESLSKVAYPITSKLY-----GGADGSGA 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	377/619 (61%)
KAR2	NP_012500.3	HSP70	52..654	CDD:394970	372/604 (62%)