Protein Alignment Hsp70Ab and Hspa12a

DIOPT Version :10

• Sequence 1: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: XP_006527440.1
• Gene: Hspa12a / 73442
• MGIID: 1920692
• Length: 695
• Species: Mus musculus
• Alignment Length: 663
• Identity: 138/663 - (20%)
• Similarity: 227/663 - (34%)
• Gaps: 216/663 - (32%)

  Fly     4 IGIDLGTTYS-----------CVGVYQHGKVEIIANDQG--NRTTPSYVAFTDSERLIGDPAKNQ 55
            :.||.|||.|           |:.|.:..:    ..|.|  |:.||:.:..|...:.      :.
Mouse    79 VAIDFGTTSSGYAYSFTKEPECIHVMRRWE----GGDPGVSNQKTPTTILLTPERKF------HS 133

  Fly    56 VAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGE-----------SK 109
            .....|:...|.         ||   .:.|.|.:.     .|.|:.:...|:           .|
Mouse   134 FGYAARDFYHDL---------DP---SEAKQWLYL-----EKFKMKLHTTGDLTMDTDLTAANGK 181

  Fly   110 RFAPEEISSMVLTKMKETAEAYLGESI------TDA--VITVPAYFNDSQRQATKDAGHIAGL-- 164
            :....||.:..|...||.|...|.:..      :|.  ||||||.:....:|..::|.:.|||
Mouse   182 KVKALEIFAYALQYFKEQALKELSDQAGSDFENSDVRWVITVPAIWKQPAKQFMREAAYQAGLAS 246

  Fly   165 ----NVLRIINEPTAAAL--------------------AYG------------------------ 181
                ..|.|..||.||::                    .|.
Mouse   247 PENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAVVNGYSASDTVGAGFAQAKEHVRRNRQSRT 311

  Fly   182 -LDKNLKGE--------RNVLIFDLGGGTFDVSI--LTIDEGSLFEVRSTAGDTH--LGGE-DFD 232
             |.:|:.||        ...::.|.||||.|:::  :.:.||.|.|:....|..:  ||.: :|:
Mouse   312 FLVENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSLGVDYEFE 376

  Fly   233 NRLVTHLADEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKV-- 295
            ..|.....::|..::|   ...|.|...|..|.|..||..:......:.|...|...|:|.|.
Mouse   377 KLLCKIFGEDFIEQFK---IKRPAAWVDLMIAFESRKRAAAPDRTNPLNITLPFSFIDYYKKFRG 438

  Fly   296 ---------SRARFEELCAD------------LFRNTLQPVEKALND--AKMDKGQIHDIVLVGG 337
                     |...|.:..:.            ||:.|:..:.:.|.|  .|.:...:..:.||||
Mouse   439 HSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGG 503

  Fly   338 STRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSG-DQSGKIQDVLLVDVAPLSLGI 401
            ....|.:|..:|..| |....:.|..|..:   ..::.|:|.| |.:     |:.|..:||:.|:
Mouse   504 FAEAPLLQQAVQTAF-GDKCRIIIPQDVGL---TILKGAVLFGLDPA-----VIKVRRSPLTYGV 559

  Fly   402 ETAGGVMTKLIE--------------RNCR------IPCKQT--------KTFSTYADNQPGVSI 438
                ||:.:.:|              |.|.      |...|:        ::::....:|..:.|
Mouse   560 ----GVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIII 620

  Fly   439 QVYEGERAMTKDN---------NALGT--FDLSG----IPPAPRGVPQIEVTFDLDANGILNVSA 488
            .:|..|.    ||         ...||  .||:|    ..||.|.:..|....|.:    :..:|
Mouse   621 NIYSSEH----DNVSFITDPGVKKCGTLRLDLTGSGGTAVPARREIQTIMQFGDTE----IKATA 677

  Fly   489 KEMSTGKAKNITI 501
            .:::|.|:..:.|
Mouse   678 VDITTSKSVKVGI 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	138/663 (21%)
Hspa12a	XP_006527440.1	ASKHA_NBD_HSP70_HSPA12A	77..543	CDD:466841	104/497 (21%)