Protein Alignment Hsp70Ab and Hsc70-5

DIOPT Version :9

• Sequence 1: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 648
• Identity: 315/648 - (48%)
• Similarity: 428/648 - (66%)
• Gaps: 46/648 - (7%)

  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            ||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|.|||.|...|..||.:..
  Fly    55 IGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYAT 119

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVV-SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||::|||::.:|:.:..:||| :..|...:.   ..:.|.::|.:|.:.:|.|||||||||
  Fly   120 KRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEAY 181

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196
            |...:.:||:||||||||||||||||||.||||||||:||||||||||||:||.  .::.:.::|
  Fly   182 LNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKIIAVYD 244

  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRL 261
            |||||||:|||.|.:| :|||:||.|||.||||||||.:|..|..|||:....|:|.:..|::||
  Fly   245 LGGGTFDISILEIQKG-VFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRL 308

  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEG----QDFYTKVSRARFEELCADLFRNTLQPVEKALNDA 322
            :.|||:||..||||.:..|.:..|...    |....|::|::.|.|..||.:.|:||.:|||:||
  Fly   309 KEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDA 373

  Fly   323 KMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQ 387
            ::.|.:|.:::||||.||:|||||.:|:.| |:..:.|:|||||||.|||||..:|:||    :.
  Fly   374 EVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD----VT 433

  Fly   388 DVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNN 452
            ||||:||.||||||||.|||.|:||.||..||.|:::.|||.:|.|..|.|:|::|||.|..||.
  Fly   434 DVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNK 498

  Fly   453 ALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMV 517
            .||:|.|.||||||||||||||.||:|||||::||||:..|||.:.|.|:: .|.||:.||:.|:
  Fly   499 LLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQS-SGGLSKDEIENMI 562

  Fly   518 NEAEKYADEDEKHRQRITSRNALESYVFNVKQAVE----QAPAGKLDEADKNSVLDKCNDTIRWL 578
            .:||:||..|::.|:.|...|..||.|.:.:..:|    |.||.:.::. |..:.|     :|.|
  Fly   563 KKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKL-KKEIAD-----LRTL 621

  Fly   579 DSNTTAEKEEFDHKLEELTRHCSPIM-----------TKMH-QQGAGAGAGGPGANCGQQAGG 629
                .|.||..|  |||:.:..|.:.           .||. ::.:.||||...::......|
  Fly   622 ----LANKETAD--LEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSG 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	315/648 (49%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	199/380 (52%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	312/634 (49%)
		HSPA9-like_NBD	51..428	CDD:212683	199/379 (53%)
		Syntaphilin	<566..>642	CDD:291936	26/87 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464212
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19375
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850