Protein Alignment Hsp70Ab and hspa4b

DIOPT Version :9

• Sequence 1: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_956151.1
• Gene: hspa4b / 334086
• ZFINID: ZDB-GENE-030131-6018
• Length: 840
• Species: Danio rerio
• Alignment Length: 709
• Identity: 201/709 - (28%)
• Similarity: 338/709 - (47%)
• Gaps: 116/709 - (16%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|.|:|.....|.|.:.|.:|.:||:..:|.||:.|:|....|.||..||:|:..|.:|||.
Zfish     1 MSVVGFDVGFLNCYVAVARAGGIETVANEYSDRCTPACVSFGPRNRSIGAAAKSQMVTNCKNTVH 65

  Fly    66 DAKRLIGRKYDD-------PKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTK 123
            ..||..||.:.|       |.:..|:...|      .|...:.|.|..|.|.|:.|::::|:|||
Zfish    66 GFKRFHGRAFSDPFVQNLKPSLVYDLAQMP------SGTTGLKVMYMEEEKVFSIEQVTAMLLTK 124

  Fly   124 MKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN--- 185
            :|||||:.|.:.:.|.||:||.::.|::|::..||..|||||.||::||.||.|||||:.|.
Zfish   125 LKETAESALKKPVADCVISVPCFYTDAERRSVIDAAQIAGLNCLRLMNETTAVALAYGIYKQDLP 189

  Fly   186 --LKGERNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYK 248
              .:..|||:..|:|...:.||:...::|.| ::.:||.|..:||:.||.|||.:..:||..|||
Zfish   190 APEEKPRNVVFVDIGHSGYQVSVCAFNKGKL-KILATAFDPEMGGKYFDERLVKYFCEEFVVKYK 253

  Fly   249 KDLRSNPRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTL 312
            .|.::.||||.||....|:.|:.:| :|::..:.|:......|..::::||:|||:|||:.....
Zfish   254 LDAKTKPRALIRLFQECEKLKKLMSANSSDLPLNIECFMNDVDVSSRLNRAQFEEMCADILARVE 318

  Fly   313 QPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAI 377
            .|:...|..|.:.|..||.:.:|||::|:|.::..:..|| ||..:.::|.|||||.|.|:|.||
Zfish   319 PPLRSLLEQAHLKKDDIHAVEIVGGASRMPAIKERISKFF-GKEPSTTLNADEAVARGCALQCAI 382

  Fly   378 LSGDQSGKIQDVLLVDVAPLSLGIE----TAGGVMTKLIERNCRI-PCKQTKTFS---TYADNQP 434
            ||  .:.|:::..:.:|.|..:.::    ...||      .:|.: |......||   |:...:|
Zfish   383 LS--PAFKVREFSITEVVPFPISLKWNSAAEDGV------SDCEVFPKNHAAPFSKVLTFYRREP 439

  Fly   435 GVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVSA---------- 488
            ......|...:.:...:..:|.:.:..:.|...| ..:::|...::.:||.:||:
Zfish   440 FTLDAYYNSPKELPYPDPTIGQYVVQKVVPQASGESSKVKVKVRVNIHGIFSVSSASLVEVQKSE 504

  Fly   489 -------------------------------------------KEMST----GK----------A 496
                                                       :||.|    ||          |
Zfish   505 EEEESMETEQSTEKENENKMQVDQEEQKTPETEQENGEKKPGTEEMETSAEEGKQEKKSDQPPQA 569

  Fly   497 KNITIK----------NDKGRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQAV 551
            |...:|          |.:.:|:...::..|....|...:|:..::|..::|.:|.||:.::..:
Zfish   570 KKPKVKTKVLDLPIENNPQWQLANDMLNLFVESEGKMIMQDKLEKERNDAKNYVEEYVYEMRDKL 634

  Fly   552 EQAPAGKLDEADKNSVLDKCNDTIRWL-DSNTTAEKEEFDHKLEELTRHCSPIMTKMHQ 609
            .......:.|:|::.:..|..||..|| :......|:.:..||.||.....||..:..:
Zfish   635 HGIFEKFVTESDRDVLSLKLEDTEVWLYEDGEDQPKQIYIDKLAELKNLGQPIQDRYRE 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	200/708 (28%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	146/388 (38%)
hspa4b	NP_956151.1	HSPA4_NBD	2..384	CDD:212687	146/389 (38%)
		HSP70	3..693	CDD:278441	200/705 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810