Protein Alignment Hsp70Ab and HSPA6

DIOPT Version :10

• Sequence 1: NP_524798.2
• Gene: Hsp70Ab / 44920
• FlyBaseID: FBgn0013276
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_002146.2
• Gene: HSPA6 / 3310
• HGNCID: 5239
• Length: 643
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 456/641 - (71%)
• Similarity: 543/641 - (84%)
• Gaps: 6/641 - (0%)

  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |:|||||||||||||:|.|:|||:|||||||||||||||||:|||:||.||:|.|:||.||||||
Human     8 AVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDA 72

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||:.|..:..|||||||:|||:|||||:.|.|:||.|.|.|||||||||:||||||||||
Human    73 KRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYL 137

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFDL 197
            |:.:..|||||||||||||||||||||.|||||||||||||||||:|||||:...||||||||||
Human   138 GQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDL 202

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLR 262
            ||||||||:|:||.| :|||::|||||||||||||||||.|..:||:||:.|||..|.|||||||
Human   203 GGGTFDVSVLSIDAG-VFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLR 266

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.|||||||||||:||:|||:||||.||||.::||||||||:||||:||:||||||.|||:||.
Human   267 TACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 331

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            ||||:|||||||||||||.||||||:||.||.|||||||||||||||||:|.||:..|:||:||:
Human   332 QIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLL 396

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||||:||||||||.||:||..||.|||:||:||:||||||.|||||||||||||||.||.|
Human   397 DVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRF 461

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            :|||||||||||||||||||:||||||:|:|.:.|||||..|||.|||||||:.|::|||:|||:
Human   462 ELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQ 526

  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQAV-EQAPAGKLDEADKNSVLDKCNDTIRWLDSNTTAEK 586
            |..|||..|.|:.::|:||::||:||.:: |::...|:.|.|:..:.|||.:.:.||:.|..|||
Human   527 YKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEK 591

  Fly   587 EEFDHKLEELTRHCSPIMTKMHQQGAGAGAGGPGANCGQQAGGFGGYSGPTVEEVD 642
            ||::|:..||.:.|.||.::::   .|.|..| |::||.||......:||.:||||
Human   592 EEYEHQKRELEQICRPIFSRLY---GGPGVPG-GSSCGTQARQGDPSTGPIIEEVD 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Ab	NP_524798.2	PTZ00009	2..642	CDD:240227	454/639 (71%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		301/380 (79%)
		PTZ00009	8..643	CDD:240227	454/639 (71%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		91/114 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..643		11/27 (41%)